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Laropiprant is a prostaglandin D2 binding drug shown to reduce niacin-induced vasodilation and flushing side effects. [ 28 ] [ 72 ] [ 73 ] A clinical trial showed no additional efficacy of Tredaptive in lowering cholesterol when used together with other statin drugs, but did show an increase in other side effects. [ 74 ]
Niacin/lovastatin (trade names Advicor) was a drug combination used for the treatment of dyslipidemia. It was a combination of the lipid-modifying drug/vitamin niacin in extended release form and the statin drug lovastatin (trade name Mevacor). [ 1 ]
While nicotinic acid (niacin) may be used for this purpose, nicotinamide has the benefit of not causing skin flushing. [4] As a cream, it is used to treat acne, and has been observed in clinical studies to improve the appearance of aging skin by reducing hyperpigmentation and redness. [5] [6] It is a water-soluble vitamin. Side effects are minimal.
In the US, niacin is also available as a dietary supplement at 500 to 1,000 mg/tablet. Niacin has sometimes been used in combination with other lipid-lowering medications. [37] Systematic reviews found no effect of niacin on cardiovascular disease or death, in spite of raising high-density lipoprotein (HDL) cholesterol. Reported side effects ...
Example of a label showing the amount of niacin (Vitamin B3), and specifying to be niacinamide in the ingredient section.. As flour fortification started adding niacin in the US, the United States Government adopted the terms niacin (a shortened form of "nicotinic acid vitamin") and niacinamide in 1942 as alternate names for nicotinic acid and nicotinamide, respectively, and encouraged their ...
Inositol nicotinate is generally safe when taken by mouth, but possible side effects include: Stomach upset; Intestinal gas; Nausea; Liver damage (similar to other niacin products) [1] It is marketed as "no-flush" niacin, but research suggests that the lack of flushing may be due to its limited conversion to active niacin. [4]
Pellagra is a disease caused by a lack of the vitamin niacin (vitamin B 3). [2] Symptoms include inflamed skin, diarrhea, dementia, and sores in the mouth. [1] Areas of the skin exposed to friction and radiation are typically affected first. [1] Over time affected skin may become darker, stiffen, peel, or bleed. [1] [3]
Dianazene was the name given by L. Ron Hubbard to a vitamin compound containing iron, vitamin C, and various B vitamins, including especially large doses of niacin.. Hubbard promoted it as a form of protection against radiation poisoning during the 1950s, saying that "Dianazene runs out radiation — or what appears to be radiation.