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Narcolepsy type 2 (NT2) does not have features of cataplexy and CSF orexin levels are normal. Sleep-related hallucinations , also known as hypnogogic (going to sleep) and hypnopompic (on awakening) are vivid hallucinations that can be auditory , visual , or tactile and may occur independent of or in combination with an inability to move ( sleep ...
Primary vs. secondary (i.e. comorbid) insomnia has been reunited into a single disorder: chronic insomnia. Narcolepsy has been divided into narcolepsy type 1 and narcolepsy type 2. These two types are distinguished by the presence or absence of cataplexy and the cerebrospinal fluid hypocretin-1 level.
This condition was first discovered in 1995 by Melberg et al. when they described 5 members of a 4-generation Swedish family where cerebellar ataxia and sensorineural deafness presented as an autosomal dominant trait, 4 of them had narcolepsy and 2 had diabetes mellitus. The oldest members had psychiatric symptoms, neurological anomalies, and ...
Danavorexton (developmental code name TAK-925) is a selective orexin 2 receptor agonist. [1] It is a small-molecule compound and is administered intravenously. [1] [2] The compound was found to dose-dependently produce wakefulness to a similar degree as modafinil in a phase 1 clinical trial.
Another underlying sleep disorder, such as narcolepsy, sleep apnea, [8] idiopathic hypersomnia, or restless legs syndrome; Disorders such as clinical depression or atypical depression [medical citation needed] Tumors, head trauma, anemia, kidney failure, hypothyroidism, or an injury to the central nervous system [9] Drug abuse [medical citation ...
Patients with sleeping disorders following TBI specifically develop insomnia, sleep apnea, narcolepsy, periodic limb movement disorder and hypersomnia. [1] [3] [4] Furthermore, circadian sleep-wake disorders can occur after TBI. [1] [3] [5]
narcolepsy, periodic limb movement disorder, restless legs syndrome, obstructive sleep apnea, central sleep apnea syndrome, sleep state misperception, psychophysiologic insomnia, recurrent hypersomnia, post-traumatic hypersomnia, central alveolar hypoventilation syndrome, Extrinsic sleep disorders – 13 disorders recognized, including [1]: 16
Pediatric narcolepsy cases are cases when patients are diagnosed or experience symptoms onset for narcolepsy before the age of 18. Of patients who obtain a formal diagnosis for narcolepsy, more than 50% report first experiencing symptoms of narcolepsy more than 10 years before their formal diagnosis, with an average age of symptom onset being at age 15 and symptom onset most likely to occur ...
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