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Hypertrophic osteoarthropathy is a medical condition combining clubbing and periostitis of the small hand joints, especially the distal interphalangeal joints and the metacarpophalangeal joints. Distal expansion of the long bones as well as painful, swollen joints [ 3 ] and synovial villous proliferation are often seen.
Other names are primary hypertrophic osteoarthropathy or Touraine-Solente-Golé syndrome. [2] It is mainly characterized by pachyderma (thickening of the skin), periostosis (excessive bone formation) and finger clubbing (swelling of tissue with loss of normal angle between nail and nail bed).
The diffuse pattern of resorption has a widely diverse differential diagnosis which includes: pyknodysostosis, collagen vascular disease and vasculitis, Raynaud's neuropathy, trauma, epidermolysis bullosa, psoriasis, frostbite, sarcoidosis, hypertrophic osteoarthropathy, acromegaly, and advanced leprosy.
Osteoarthritis (OA) is a type of degenerative joint disease that results from breakdown of joint cartilage and underlying bone. [5] [6] It is believed to be the fourth leading cause of disability in the world, affecting 1 in 7 adults in the United States alone. [7]
Renal osteodystrophy has been classically described to be the result of hyperparathyroidism secondary to hyperphosphatemia combined with hypocalcemia, both of which are due to decreased excretion of phosphate by the damaged kidney.
One theory is that hypertrophic osteopathy is caused by increased blood flow to the ends of the legs, overgrowth of connective tissue, and then new bone formation surrounding the bones. [6] This is secondary to nerve stimulation by the lung disease. The condition may reverse if the lung mass is removed or if the vagus nerve is cut on the ...
In a hypertrophic nonunion, the fracture site contains adequate blood supply but the fracture ends fail to heal together. [6] X-rays show abundant callus formation. This type of nonunion is thought to occur when the body has adequate biology, such as stem cells and blood supply, but inadequate stability, meaning the bone ends are moving too much.
In 1889, he provided a detailed description of a condition that has become known as hypertrophic pulmonary osteoarthropathy. During the following year, French neurologist Pierre Marie (1853–1940) was able to differentiate the syndrome from acromegaly. The term "Bamberger-Marie disease" is sometimes used for hypertrophic pulmonary ...