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Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a slow-growing CD20 positive form of Hodgkin lymphoma, a cancer of the immune system's B cells. [1] [2]NLPHL is an uncommon sub-type of Hodgkin lymphoma, making up 5-10% of Hodgkin lymphomas. [3]
Ann Arbor staging is the staging system for lymphomas, both in Hodgkin's lymphoma (formerly designated Hodgkin's disease) and non-Hodgkin lymphoma (abbreviated NHL). It was initially developed for Hodgkin's, but has some use in NHL. It has roughly the same function as TNM staging in solid tumors.
A special type of Reed–Sternberg cell (RSC) is the lacunar histiocyte, whose cytoplasm retracts when fixed in formalin, so the nuclei give the appearance of cells that lie with empty spaces (called lacunae) between them. [4]
T-cell/histiocyte-rich large B-cell lymphoma (THRLBCL) is a malignancy of B cells.B-cells are lymphocytes that normally function in the humoral immunity component of the adaptive immune system by secreting antibodies that, for example, bind to and neutralize invasive pathogens.
Burkitt's lymphoma is a cancer of the lymphatic system, particularly B lymphocytes found in the germinal center.It is named after Denis Parsons Burkitt, the Irish surgeon who first described the disease in 1958 while working in equatorial Africa.
Monoclonal B-cell lymphocytosis (MBL) is an asymptomatic condition in which individuals have increased blood levels of particular subtypes of monoclonal lymphocytes (i.e. an aberrant and potentially malignant group of lymphocytes produced by a single ancestral cell).
Histology of a normal lymphoid follicle, with marginal zone annotated at bottom.. Numerous factors appear to be involved in the development of EMZL. In a small number of cases where there is a family history of a blood cancer particularly leukemia, or a number of autoimmune diseases such as Sjögren syndrome and lupus erythematosus, there is seen to be an increased frequency.
12482 Ensembl ENSG00000156738 ENSMUSG00000024673 UniProt P11836 P19437 RefSeq (mRNA) NM_152866 NM_021950 NM_152867 NM_007641 RefSeq (protein) NP_068769 NP_690605 NP_690606 NP_031667 Location (UCSC) Chr 11: 60.46 – 60.47 Mb Chr 19: 11.23 – 11.24 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse B-lymphocyte antigen CD20 or CD20 is B lymphocyte cell-surface molecule. It is a 33-37 ...