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Lobules of liver. The structure of the liver’s functional units or lobules. Blood enters the lobules through branches of the portal vein and hepatic artery proper, then flows through sinusoids. In histology (microscopic anatomy), the lobules of liver, or hepatic lobules, are small divisions of the liver defined at the microscopic scale.
Anatomical terms of microanatomy. [edit on Wikidata] A hepatocyte is a cell of the main parenchymal tissue of the liver. Hepatocytes make up 80% of the liver's mass. These cells are involved in: Protein synthesis. Protein storage. Transformation of carbohydrates. Synthesis of cholesterol, bile salts and phospholipids.
Definitions. Cytology is the name given to the branch of biology that deals with the formation, structure and functionality of the cells. [1] Liver cytology specializes in the study of liver cells. The main liver cells are called hepatocytes; however, there are other cells that can be observed in a liver sample such as Kupffer cells ...
Hepatic stellate cells (HSC), also known as perisinusoidal cells or Ito cells (earlier lipocytes or fat-storing cells), are pericytes found in the perisinusoidal space of the liver, also known as the space of Disse (a small area between the sinusoids and hepatocytes). The stellate cell is the major cell type involved in liver fibrosis, which is ...
Old or defective cells are removed through apoptosis, as well as through being phagocytized by neighbouring Kupffer cells. Kupffer cells are heterogeneous in their function, dependent on their location in the liver lobules. Cells in the periportal zone are directly exposed to bloodflow, and express greater lysosomal activity to more efficiently ...
In very severe cases, as the condition progresses, you might experience: Jaundice (when your skin or the whites of your eyes turn yellow due to liver damage) Swelling in your abdomen or legs. If ...
HepaRG cell line is a human hepatic in vitro line used in liver biology research and for assessing liver pathology, hepatotoxicity, and drug-induced injury. The HepaRG model is considered a surrogate for Primary Human Hepatocytes, which are the most pertinent model to reproduce the human liver functioning as they express 99% of the same genes .
Liver regeneration is the process by which the liver is able to replace damaged or lost liver tissue. The liver is the only visceral organ with the capacity to regenerate. [ 1 ] [ 2 ] The liver can regenerate after partial hepatectomy or injury due to hepatotoxic agents such as certain medications, toxins, or chemicals. [ 3 ]