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  2. Hydrocodone - Wikipedia

    en.wikipedia.org/wiki/Hydrocodone

    Hydrocodone is a highly selective full agonist of the μ-opioid receptor (MOR). [28] [54] [49] This is the main biological target of the endogenous opioid neuropeptide β-endorphin. [55] Hydrocodone has low affinity for the δ-opioid receptor (DOR) and the κ-opioid receptor (KOR), where it is an agonist similarly. [49]

  3. Hydromorphone - Wikipedia

    en.wikipedia.org/wiki/Hydromorphone

    Hydromorphone, also known as dihydromorphinone, and sold under the brand name Dilaudid among others, is a morphinan opioid used to treat moderate to severe pain. [7] Typically, long-term use is only recommended for pain due to cancer. [9]

  4. Extended-release morphine - Wikipedia

    en.wikipedia.org/wiki/Extended-release_morphine

    According to a Cochrane review in 2013, extended-release morphine as an opioid replacement therapy for people with heroin addiction or dependence confers a possible reduction of opioid use and with fewer depressive symptoms but overall more adverse effects when compared to other forms of long-acting opioids. The length of time in treatment was ...

  5. Purdue Pharma, Sacklers reach $7.4 billion national opioid ...

    www.aol.com/news/purdue-pharma-sacklers-reach-7...

    Purdue Pharma and its Sackler family owners have reached a new $7.4 billion settlement to resolve thousands of lawsuits alleging that the pain medication OxyContin caused a widespread opioid ...

  6. Methadone - Wikipedia

    en.wikipedia.org/wiki/Methadone

    The metabolic half-life is 8 to 59 hours (approximately 24 hours for opioid-tolerant people, and 55 hours for opioid-naive people), as opposed to a half-life of 1 to 5 hours for morphine. [12] The length of the half-life of methadone allows for the exhibition of respiratory depressant effects for an extended duration of time in opioid-naive people.

  7. Colorado set to receive $82 million in Purdue Pharma settlement

    www.aol.com/news/colorado-set-receive-82-million...

    Colorado’s portion would be part of a $7.4 billion settlement in principle with U.S. states and the family for “their central role in creating the opioid crisis,” the attorney general’s ...

  8. Opioid agonist therapy - Wikipedia

    en.wikipedia.org/wiki/Opioid_agonist_therapy

    The difference between an opioid and an opioid agonist is that opioids induce more intense effects and stay in the brain for a short amount of time. [3] Conversely, an opioid agonist induces minimal effects and stays in the brain for a long time, which prevents the opioid user from feeling the effects of natural or synthetic opioids. [3]

  9. Cancel or reactivate your AOL account

    help.aol.com/articles/account-management-cancel...

    If you aren't already on your Subscriptions page, click My Services | My Subscriptions. Click Manage next to the plan you'd like to cancel. Click Cancel. At the bottom of the page, click Cancel My Billing. Select a reason for canceling from the drop-down menu. Click Cancel My Billing. Things to know when you change your AOL account to the free ...