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A 1977 article compares the "classical" trapezoidal method to a number of methods that take into account the typical shape of the concentration plot, caused by first-order kinetics. [8] Notwithstanding the above knowledge, a 1994 Diabetes Care article by Mary M. Tai purports to have independently discovered the trapezoidal rule. [9]
After reaching the CMC, the surface tension remains relatively constant or changes with a lower slope. The value of the CMC for a given dispersant in a given medium depends on temperature, pressure, and (sometimes strongly) on the presence and concentration of other surface active substances and electrolytes .
For a response of 0.25a.u., Drug B is more potent, as it generates this response at a lower concentration. For a response of 0.75a.u., Drug A is more potent. a.u. refers to "arbitrary units". In pharmacology , potency or biological potency [ 1 ] is a measure of a drug's biological activity expressed in terms of the dose required to produce a ...
Note 1: An amphiphilic behavior can be observed for water and an organic solvent or between two organic solvents. Note 2: Polymeric micelles have a much lower critical micellar concentration (CMC) than soap (0.0001 to 0.001 mol/L) or surfactant micelles, but are nevertheless at equilibrium with isolated macromolecules called unimers.
It is the same concept as volume percent (vol%) except that the latter is expressed with a denominator of 100, e.g., 18%. The volume fraction coincides with the volume concentration in ideal solutions where the volumes of the constituents are additive (the volume of the solution is equal to the sum of the volumes of its ingredients).
In quantitative situations, the Y-axis often is designated by percentages, which refer to the percentage of exposed individuals registering a standard response (which may be death, as in LD 50). Such a curve is referred to as a quantal dose–response curve, distinguishing it from a graded dose–response curve, where response is continuous ...
Hydrophilic interaction chromatography (or hydrophilic interaction liquid chromatography, HILIC) [1] is a variant of normal phase liquid chromatography that partly overlaps with other chromatographic applications such as ion chromatography and reversed phase liquid chromatography.
The V e component represents the volume at which the intermediate molecules elute such as molecules that have partial access to the beads of the column. In addition, V t is the sum of the total volume between the beads and the volume within the beads. The V o component represents the volume at which the larger molecules elute, which elute in ...