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Belimumab, sold under the brand name Benlysta, is a human monoclonal antibody that inhibits B-cell activating factor (BAFF), [6] also known as B-lymphocyte stimulator (BLyS). [7] It is approved in the United States [ 8 ] and Canada, [ 9 ] and the European Union [ 5 ] to treat systemic lupus erythematosus and lupus nephritis.
“There are many medications that may cause weight gain,” says W. Scott Butsch, M.D., director of obesity medicine in the Bariatric and Metabolic Institute at the Cleveland Clinic.
Setmelanotide is an agonist of the melanocortin 4 receptor and is used in people with certain rare genetic conditions that cause obesity. It is less effective and not approved for general obesity. [16] Some weight loss drugs act on the neurotransmitters serotonin, dopamine, and norepinephrine to reduce appetite. [17]
Rather, the question should be “Does B12 deficiency cause weight gain” as some evidence suggests low levels of B12 may be linked to weight gain and obesity.
Lack of sufficient sleep has been suggested as a cause for weight gain or the difficulty in maintaining a healthy weight. [10] Two hormones responsible for regulating hunger and metabolism are leptin, which inhibits appetite and increases energy expenditure, and ghrelin, which increases appetite and reduces energy expenditure. [10]
It's very common for weight gain to start during perimenopause, a few years before menopause, per Mayo Clinic. For many women, this can start in their 40s, and weight gain often continues at about ...
Thiazolidinediones may cause slight weight gain but decrease "pathologic" abdominal fat (visceral fat), and therefore may be prescribed for diabetics with central obesity. [115] Thiazolidinedione has been associated with heart failure and increased cardiovascular risk; so it has been withdrawn from the market in Europe by EMA in 2010. [116]
Many common antidepressants can cause weight gain over time, but that's not a reason to avoid taking medication for mental health issues, experts say. - Joe Raedle/Getty Images/File