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Varenicline, sold under the brand names Chantix and Champix among others, is a medication used for smoking cessation [5] [7] and for the treatment of dry eye syndrome. [ 6 ] [ 8 ] It is a nicotinic acetylcholine receptor partial agonist .
Varenicline tartrate: Champix, Chantix 7,8,9,10-tetrahydro-6,10-methano-6H-pyrazino[2,3-h][3]benzazepine [27] Film coated tablet Partial agonist of the nicotinic acetylcholine receptor, subtype α 4 β 2 [28] Treatment of tobacco dependence [28] Galantamine hydrobromide: Reminyl, Nivalin, Razadyne and Razadyn ER
Nicotine inhalers are metered-dose inhalers [citation needed] that administer nicotine through the lungs and mucous membranes of the throat quickly, lasting for a short amount of time. For example, blood nicotine levels are the highest 5–10 minutes after using the nicotine nasal spray , 20 minutes after using a nicotine inhaler or chewing ...
Varenicline works exactly like nicotine, and we could perfectly do patches and inhalers of varenicline. The difference between varenicline and nicotine, is that the former affects only some nicotinic receptors, and affect them partially. Since nicotine has many effects on the brain, positive and negative, it is better.
ATC code N07 Other nervous system drugs is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed by the World Health Organization (WHO) for the classification of drugs and other medical products.
A 2013 meta-analysis of eight studies demonstrated that cytisine has similar effectiveness to varenicline but with substantially lower side effects. [13] A 2014 systematic review and economic evaluation concluded that cytisine was more likely to be cost-effective for smoking cessation than varenicline. [14]
The Recent work has demonstrated a potential role in reducing inflammatory neurotoxicity in stroke, myocardial infarction, sepsis, and Alzheimer's disease. [4] [5] [6]The α7 receptor is highly implicated in the efficacy of Varenicline for smoking cessation therapy significantly more than α4β2 which is responsible for Nicotine's rewarding effects.
An auxiliary label (also called cautionary and advisory label or prescription drug warning label) is a label added on to a dispensed medication package by a pharmacist in addition to the usual prescription label. These labels are intended to provide supplementary information regarding the safe administration, use, and storage of the medication. [1]
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