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The 30S subunit is the target of antibiotics such as tetracycline and gentamicin. [11] These antibiotics specifically target the prokaryotic ribosomes, hence their usefulness in treating bacterial infections in eukaryotes. Tetracycline interacts with H27 in the small subunit as well as binding to the A-site in the large subunit. [11]
Inhibits bacterial protein synthesis by binding to the 50S subunit of the ribosome Fosfomycin: Monurol, Monuril: Acute cystitis in women: This antibiotic is not recommended for children and 75 and up of age: Inactivates enolpyruvyl transferase, thereby blocking cell wall synthesis Fusidic acid: Fucidin: Metronidazole: Flagyl
Protein TolC, the outer membrane component of a tripartite efflux pump in Escherichia coli. AcrB, the other component of pump, Escherichia coli. An efflux pump is an active transporter in cells that moves out unwanted material. Efflux pumps are an important component in bacteria in their ability to remove antibiotics. [1]
Puromycin is stable for one year as solution when stored at -20 °C. The recommended dose as a selection agent in cell cultures is within a range of 1-10 μg/mL, although it can be toxic to eukaryotic cells at concentrations as low as 1 μg/mL. Puromycin acts quickly and can kill more than 99% of nonresistant cells within one day. [citation needed]
Cells can become resistant to tetracycline by enzymatic inactivation of tetracycline, efflux, ribosomal protection, [2] reduced permeability and ribosome mutation. [ 5 ] Inactivation is the rarest type of resistance, [ 32 ] where NADPH-dependent oxidoreductase , a class of antibiotic destructase, modifies the tetracycline antibiotic at their ...
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
The two types of beta-lactamases work on the basis of the two basic mechanisms of opening the β-lactam ring. [2]The SBLs are similar in structure and mechanistically to the β-lactam target penicillin-binding proteins (PBPs) which are necessary for cell wall building and modifying.
Cresomycin has been found to effective against bacteria that are resistant to multible antibiotics, including lincosamides, both in vitro and in vivo, being more potent than iboxamycin. [1] The antibiotic was found in time-kill studies to be bacteriostatic against S. aureus. In vitro safety experiments with human cells indicated low ...