Search results
Results from the WOW.Com Content Network
Misoprostol by mouth is the least effective treatment for producing complete abortion in a period of 24 hours due to the liver's first-pass effect which reduces the bioavailability of the misoprostol. Vaginal and sublingual routes result in greater efficacy and extended duration of action because these routes of administration allow the drug to ...
Methotrexate is given either orally or intramuscularly, followed by vaginal misoprostol 3–5 days later. [22] The methotrexate combination is available through 63 days. The WHO authorizes the methotrexate-misoprostol combination [ 42 ] but recommends the mifepristone combination because methotrexate may be teratogenic to the embryo in cases of ...
For first-trimester abortion, it is dissolved in the cheek or under the tongue; for later abortions, it can also be given as a vaginal suppository. Misoprostol may also be used to ripen the cervix in preparation for surgical abortion. [20] Misoprostol is given orally for the treatment of ulcers.
In Great Britain and Sweden, mifepristone is licensed for use with vaginal gemeprost or oral misoprostol. As of 2000, more than 620,000 women in Europe had had medication abortions using a mifepristone regimen. [98] In Denmark, mifepristone was used in between 3,000 and 4,000 of just over 15,000 abortions in 2005. [99]
This page was last edited on 7 December 2020, at 15:48 (UTC).; Text is available under the Creative Commons Attribution-ShareAlike 4.0 License; additional terms may apply.
Prostaglandin E 2 (PGE 2), also known as dinoprostone, is a naturally occurring prostaglandin with oxytocic properties that is used as a medication. [2] [3] [4] Dinoprostone is used in labor induction, bleeding after delivery, termination of pregnancy, and in newborn babies to keep the ductus arteriosus open.
Prostaglandin F 2α (PGF 2α in prostanoid nomenclature), pharmaceutically termed dinoprost, is a naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient. [1]
The routes of administration include sublingual, oral, vaginal, and rectal with greatest efficacy from sublingual and vaginal administration. Vaginally administered misoprostol had improved outcomes of inducing labor within twenty four hours compared to oxytocin, but was associated with uterine hyperstimulation. [15]