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Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic obesity in adults in combination with a reduced-calorie diet and increased physical activity. [4] [6] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone atypical antidepressant. [4]
In clinical trials, the most common adverse events which occurred at a rate ≥5% and ≥1.5 times placebo included paraesthesia (tingling in fingers/toes), dizziness, altered taste, insomnia, constipation, and dry mouth.
Sold under the brand name Qsymia, it is a combination of the drugs phentermine and topiramate, which are taken orally. The medications are used, along with changes in diet and exercise habits, to ...
Only 13% of patients who started taking Contrave from Orexigen Therapeutics and 10% of those who started on Qsymia from Vivus between 2015 and 2022 were still filling their prescriptions a year ...
Qsymia Phentermine is a substituted amphetamine and topiramate has an unknown mechanism of action Approved for weight management (short-term) by the FDA but not the European Medicines Agency [54] 10% [55] or 8.25 kilograms (18.2 lb) [56] Naltrexone/bupropion: Contrave Approved for weight management (chronic) in the US and EU [57] 5 percent [17 ...
Obese patients have seen more choices for treatments over the past year, as new obesity drugs from VIVUS and Arena Pharmaceuticals have launched. A third drug, Orexigen's Contrave, looks as if it ...
Vivus got Qsymia approved, and Orexigen is still developing Contrave. What role do drugs really play in treatment? Dr. Domenica Rubino: A fundamental thing to understand is that the physiology of ...
Contrave (naltrexone-bupropion) Qsymia (phentermine-topiramate) Xenical (orlistat) Topamax (topiramate) Beyond medications, diet and exercise plans and behavioral change tools can help if you’ve ...
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