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Aspirin is the genericized trademark for acetylsalicylic acid (ASA), a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and inflammation, and as an antithrombotic. [10] Specific inflammatory conditions that aspirin is used to treat include Kawasaki disease , pericarditis , and rheumatic fever .
Salicylic acid is an organic compound with the formula HOC 6 H 4 COOH. [3] A colorless (or white), bitter-tasting solid, it is a precursor to and a metabolite of acetylsalicylic acid (aspirin). [3] It is a plant hormone, [8] and has been listed by the EPA Toxic Substances Control Act (TSCA) Chemical Substance Inventory as an experimental ...
Fumaric acid is (E)-1,4-but-2-enedioic acid, a trans isomer, whereas maleic acid is the corresponding cis isomer, i.e. (Z)-1,4-but-2-enedioic acid (see cis-trans isomerism). Fumaric acid has pK a values of approximately 3.0 and 4.5. By contrast, maleic acid has pK a values of approximately 1.5 and 6.5.
A simple buffer solution consists of a solution of an acid and a salt of the conjugate base of the acid. For example, the acid may be acetic acid and the salt may be sodium acetate . The Henderson–Hasselbalch equation relates the pH of a solution containing a mixture of the two components to the acid dissociation constant , K a of the acid ...
Alka-Seltzer is a combination of sodium bicarbonate, aspirin, and anhydrous citric acid used for the relief of heartburn, acid indigestion, and stomach aches. [7] Alka-Seltzer is sold in foil packets, each containing two tablets. Prior to 1984, it was also available stacked in cylindrical glass bottles. It is available in many different flavors.
Copper aspirinate can be prepared by several methods. In one route of preparation, an excess of acetylsalicylic acid is dissolved in aqueous sodium carbonate. Sodium hydroxide is not suitable for this purpose, because it will hydrolyse acetylsalicylic acid (ASA) into salicylic acid and sodium acetate. 2 HC 9 H 7 O 4 + Na 2 CO 3 → 2 NaC 9 H 7 ...
Structure of COX-2 inactivated by Aspirin. In the active site of each of the two enzymes, Serine 516 has been acetylated. Also visible is the salicylic acid which has transferred the acetyl group, and the heme cofactor. There are at least two different cyclooxygenase isozymes: COX-1 (PTGS1) and COX-2 (PTGS2).
The enzyme acetylsalicylate deacetylase (EC 3.1.1.55) catalyzes the reaction . acetylsalicylate + H 2 O salicylate + acetate. This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds.