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Scurvy is a deficiency disease (state of malnutrition) resulting from a lack of vitamin C (ascorbic acid). [1] Early symptoms of deficiency include weakness, fatigue, and sore arms and legs. [1] [2] Without treatment, decreased red blood cells, gum disease, changes to hair, and bleeding from the skin may occur.
In April 2021, the US National Institutes of Health (NIH) COVID-19 Treatment Guidelines stated that "there are insufficient data to recommend either for or against the use of vitamin C for the prevention or treatment of COVID-19." [125] In an update posted December 2022, the NIH position was unchanged:
A 1747 study found the treatment for scurvy. A man accused of ‘quackery’ may have inspired it. Ashley Strickland, CNN. January 20, 2025 at 10:33 AM.
Kwashiorkor is associated with a high risk of mortality and long-term complications. Treatment under the guidelines of the World Health Organization has proven to reduce this mortality risk and affected children tend to recover faster than children with other severe malnutrition diseases.
Scurvy is a disease caused by a vitamin C deficiency, but in Lind's day, the concept of vitamins was unknown. Vitamin C is necessary for healthy connective tissue. In 1740 the catastrophic result of then-Commodore George Anson's circumnavigation attracted much attention in Europe; out of 1900 men, 1400 died, most of them allegedly from scurvy ...
The steps for designing explicit, evidence-based guidelines were described in the late 1980s: formulate the question (population, intervention, comparison intervention, outcomes, time horizon, setting); search the literature to identify studies that inform the question; interpret each study to determine precisely what it says about the question ...
As for vitamin C, vitamin deficiency in scurvy patients is a causative factor but no current literature reports acute and subacute vitamin C deficiency. For future research, more advanced study designs such as randomized clinical trials are needed to evaluate therapy by means of vitamin supplements.
The number of treatment units (subjects or groups of subjects) assigned to control and treatment groups, affects an RCT's reliability. If the effect of the treatment is small, the number of treatment units in either group may be insufficient for rejecting the null hypothesis in the respective statistical test .