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Folate in the form of folic acid is used to treat anemia caused by folate deficiency. [3] Folic acid is also used as a supplement by women during pregnancy to reduce the risk of neural tube defects (NTDs) in the baby. [3] [10] NTDs include anencephaly and spina bifida, among other defects.
Signs of folate deficiency anemia most of the time are subtle. [4] Anemia (macrocytic, megaloblastic anemia) can be a sign of advanced folate deficiency in adults. [1] Folate deficiency anemia may result in feeling tired, weakness, changes to the color of the skin or hair, open sores on the mouth, shortness of breath, palpitations, lightheadedness, cold hands and feet, headaches, easy bleeding ...
Download as PDF; Printable version; In other projects ... Folates are derivatives of folic acid. ... Folinic acid; 5-Formiminotetrahydrofolate ...
Government-mandated fortification of foods with folic acid has reduced the incidence of NTDs by 25% to 50% in more than 60 countries using such fortification. [10] Deficiency can also result from rare genetic factors, such as mutations in the MTHFR gene that lead to compromised folate metabolism.
The study found a significant effect on heart health in a low-salt diet, and a small effect due to omega-3 and folic acid supplements. [43] This analysis supports the results of two early 2018 studies that found no conclusive benefits from multivitamins for healthy adults. [6] [44]
One study in 184 premature infants, reported that individuals given monthly vitamin B 12 injections (100 μg) or taking supplements of vitamin B 12 and folic acid (100 μg/day), had higher haemoglobin concentrations after 10–12 weeks, compared to those only taking folic acid or those taking no vitamin B 12 injections. [87]
For example, B 9 is folic acid and five of the folates are in the range B 11 through B 16. Others, such as PABA (formerly B 10 ), are biologically inactive, toxic, or with unclassifiable effects in humans, or not generally recognised as vitamins by science, [ 82 ] such as the highest-numbered, which some naturopath practitioners call B 21 and B ...
Folinic acid is a metabolically active form of folate that can be easily introduced into the folate cycle. A typical dose that is administered to children is 0.5–1 mg/kg daily, but the dose can be increased depending on the severity of symptoms and the age of the child.