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Hartnup disease (also known as "pellagra-like dermatosis" [1] and "Hartnup disorder" [2]) is an autosomal recessive [3] metabolic disorder affecting the absorption of nonpolar amino acids (particularly tryptophan that can be, in turn, converted into serotonin, melatonin, and niacin).
Niacin is a common vitamin found in many foods, including meat, fish, nuts, grains and cereals, according to the National Institutes of Health. Eating these foods allows most Americans to consume ...
Niacin deficiency is a consequence of a diet low in both niacin and the amino acid tryptophan, a precursor for the vitamin. Low plasma tryptophan is a non-specific indicator, meaning it can have other causes. The signs and symptoms of niacin deficiency start to revert within days of oral supplementation with large amounts of the vitamin. [23] [24]
Carcinoid syndrome thus may produce niacin deficiency and clinical manifestations of pellagra. Anti-tuberculosis medication tends to bind to vitamin B 6 and reduce niacin synthesis, since B 6 (pyridoxine) is a required cofactor in the tryptophan-to-niacin reaction. Several therapeutic drugs can provoke pellagra.
The predominant cause of nutritional optic neuropathy is thought to be deficiency of B-complex vitamins, particularly thiamine [2] (vitamin B 1), cyanocobalamin (vitamin B 12) and recently copper. [3] Deficiency of pyridoxine (vitamin B 6), niacin (vitamin B 3), riboflavin (vitamin B 2), and/or folic acid also seems to play a role. Those ...
Autoimmune disorders are also a cause for small bacterial growth in the bowel and a deficiency of Vitamin B-12. These have also proved to be factors of acid secretion in the stomach. [ 7 ] Autoimmune conditions can often be managed with various treatments; however, little is known about how or if these treatments effect achlorhydria.
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Pellagra (niacin or vitamin B 3 deficiency) [6] Gastroesophageal reflux disease, in such cases specifically called a water brash (a loosely defined lay term), and is characterized by a sour fluid or almost tasteless saliva in the mouth [7] Gastroparesis (main symptoms are nausea, vomiting, and reflux) Pregnancy; Fluoride therapy; Excessive ...