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  2. SR9009 - Wikipedia

    en.wikipedia.org/wiki/SR9009

    SR9009, also known as Stenabolic, is a research drug that was developed by professor Thomas Burris of the Scripps Research Institute as an agonist of Rev-ErbA (i.e., increases the constitutive repression of genes regulated by Rev-ErbA) [1] with a half-maximum inhibitory concentration (IC 50) = 670 nM for Rev-ErbAα and IC 50 = 800 nM for Rev-ErbAβ. [2]

  3. Structural scheduling of synthetic cannabinoids - Wikipedia

    en.wikipedia.org/wiki/Structural_scheduling_of...

    Indole-3-carboxylate esters: Any compound containing a 1H-indole-3-carboxylate ester structure with the ester oxygen bearing a napthyl, quinolinyl, isoquinolinyl, or adamantyl group and substitution at the one position of the indole ring by an alkyl, haloalkyl, alkenyl, cycloalkylmethyl, cycloalkylethyl, benzyl, N-methyl-2-piperidinylmethyl, or ...

  4. Carboxylic acid - Wikipedia

    en.wikipedia.org/wiki/Carboxylic_acid

    Electron-withdrawing substituents, such as -CF 3 group, give stronger acids (the pK a of acetic acid is 4.76 whereas trifluoroacetic acid, with a trifluoromethyl substituent, has a pK a of 0.23). Electron-donating substituents give weaker acids (the pK a of formic acid is 3.75 whereas acetic acid, with a methyl substituent, has a pK a of 4.76)

  5. Methyl group - Wikipedia

    en.wikipedia.org/wiki/Methyl_group

    This is a free rotation only in the simplest cases like gaseous methyl chloride CH 3 Cl. In most molecules, the remainder R breaks the C ∞ symmetry of the R−C axis and creates a potential V(φ) that restricts the free motion of the three protons. For the model case of ethane CH 3 CH 3, this is discussed under the name ethane barrier. In ...

  6. Methylation - Wikipedia

    en.wikipedia.org/wiki/Methylation

    For example, a carboxylate may be methylated on oxygen to give a methyl ester; an alkoxide salt RO − may be likewise methylated to give an ether, ROCH 3; or a ketone enolate may be methylated on carbon to produce a new ketone. The Purdie methylation is a specific for the methylation at oxygen of carbohydrates using iodomethane and silver ...

  7. β-Carboline - Wikipedia

    en.wikipedia.org/wiki/Β-Carboline

    Moreover, 3-hydroxymethyl-beta-carboline blocks the sleep-promoting effect of flurazepam in rodents and – by itself – can decrease sleep in a dose-dependent manner. [16] Another derivative, methyl-β-carboline-3-carboxylate, stimulates learning and memory at low doses but can promote anxiety and convulsions at high doses. [15]

  8. Knorr pyrrole synthesis - Wikipedia

    en.wikipedia.org/wiki/Knorr_pyrrole_synthesis

    The Knorr pyrrole synthesis is a widely used chemical reaction that synthesizes substituted pyrroles (3). [1] [2] [3] The method involves the reaction of an α-amino-ketone (1) and a compound containing an electron-withdrawing group (e.g. an ester as shown) α to a carbonyl group (2). [4] The Knorr pyrrole synthesis

  9. Aminomethyl group - Wikipedia

    en.wikipedia.org/wiki/Aminomethyl_group

    Usually aminomethyl groups feature tertiary amines. Often they are obtained by alkylation with Eschenmoser's salt, a source of [CH 2 =N(CH 3) 2] +. A cobalt(III) complex of aminomethyl is known in the form [Co 2 (CH 2 NH 2)](ClO4) 2. [1] Aminomethyl is the first member of a series of 1-aminoalkyl groups of the form −(CH 2 −) n NH 2. [2]

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