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Sotagliflozin (Inpefa) is a dual SGLT1/SGLT2 inhibitor approved by the US Food and Drug Administration (FDA) in May 2023, to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with heart failure or type 2 diabetes, chronic kidney disease, and other cardiovascular risk factors ...
Dapagliflozin is used along with diet, exercise, and usually with other glucose-lowering medications, to improve glycaemic control in adults with type 2 diabetes. . Dapagliflozin, in addition to other SGLT2-inhibitors, was shown to reduce the rate of decline in kidney function and kidney failure in non-diabetic and type 2 diabetic adults when added to the existing treatment
People with heart failure, also known as congestive heart failure (CHF), are educated to undertake various non-pharmacological measures to improve symptoms and prognosis. Such measures include: [2] Moderate physical activity, when symptoms are mild or moderate; or bed rest when symptoms are severe. In individuals with heart failure, increasing ...
A study by 49 academics argued that the dissonance between the 2021 guidelines and the previous guideline was the result of deviating from usual scientific standards of the NICE process. [45] NICE responded that they did follow the standard GRADE approach , and evidence from unblinded trials with subjective outcomes was appropriately downgraded.
The American Diabetes Association and European Association for the Study of Diabetes recommend using a GLP-1 receptor agonist or SGLT2 inhibitor as the first-line treatment in patients who have or are at high risk for atherosclerotic cardiovascular disease, heart failure, or chronic kidney disease.
The so-called "classical 3-point MACE" is defined as a composite of nonfatal stroke, nonfatal myocardial infarction, and cardiovascular death. [4] [5] But another study defines MACE as "CVD events, admission for HF (Heart Failure), ischemic cardiovascular [CV] events, cardiac death, or MACE". [6]
A 2013 study analyzing 8907 interventional trials registered in ClinicalTrials.gov found that 23.2% of trials had abstract-linked result articles and 7.3% of trials had registry-linked articles. 2.7% of trials had both types of links. Most trials are linked to a single result article (76.4%). [24]
Trial design was further influenced by the large-scale ISIS trials on heart attack treatments that were conducted in the 1980s. [27] By the late 20th century, RCTs were recognized as the standard method for "rational therapeutics" in medicine. [28] As of 2004, more than 150,000 RCTs were in the Cochrane Library. [26]
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