Search results
Results from the WOW.Com Content Network
The duration of diazepam's peak pharmacological effects is 15 minutes to one hour for both routes of administration. [67] The half-life of diazepam, in general, is 30–56 hours. [ 1 ] Peak plasma levels occur between 30 and 90 minutes after oral administration and between 30 and 60 minutes after intramuscular administration; after rectal ...
Fear is the body’s natural response to something it picks up on as dangerous or threatening. ... Symptoms typically peak within 10 minutes and typically last 20 ... (Xanax®), diazepam (Valium ...
Long-acting benzodiazepines with long-acting active metabolites, such as diazepam and chlordiazepoxide, are often prescribed for benzodiazepine or alcohol withdrawal as well as for anxiety if constant dose levels are required throughout the day. Shorter-acting benzodiazepines are often preferred for insomnia due to their lesser hangover effect.
However, single very high doses of diazepam have been found to cause lifelong immunosuppression in neonatal rats. No studies have been done to assess the immunotoxic effects of diazepam in humans; however, high prescribed doses of diazepam, in humans, have been found to be a major risk of pneumonia, based on a study of people with tetanus.
Dion, who was taking Valium so she could perform, gradually built a tolerance and at one point was taking 90 milligrams a day — far beyond the maximum recommended dosage of 40 milligrams.
The inhibitory effect of the available GABA is potentiated, leading to sedative and anxiolytic effects. For instance, those ligands with high activity at the α 1 are associated with stronger hypnotic effects, whereas those with higher affinity for GABA A receptors containing α 2 and/or α 3 subunits have good anti-anxiety activity.
Rare but serious side effects include rash, itching, yellowing of the skin, swelling of the face and throat, problems speaking, difficulty swallowing and changes in memory, personality or ability ...
Chlordiazepoxide, 5 mg capsules, are sometimes used as an alternative to diazepam for benzodiazepine withdrawal. Like diazepam, it has a long elimination half-life and long-acting active metabolites. [25] [69] Management of benzodiazepine dependence involves considering the person's age, comorbidity and the pharmacological pathways of ...