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Herpetic simplex keratitis is a form of keratitis caused by recurrent herpes simplex virus (HSV) infection in the cornea. [ 1 ] It begins with infection of epithelial cells on the surface of the eye and retrograde infection of nerves serving the cornea. [ 2 ]
Idoxuridine is mainly used topically to treat herpes simplex keratitis. [3] Epithelial lesions, especially initial attacks presenting with a dendritic ulcer, are most responsive to therapy, while infection with stromal involvement are less responsive. [4] Idoxuridine is ineffective against herpes simplex virus type 2 and varicella-zoster. [3]
Herpes simplex keratitis occurs due to latent HSV reactivation in the ophthalmic nerve (the V1 branch of the trigeminal nerve). [3] Herpes keratitis is classically associated with a branching (dendritic) infiltrate pattern of inflammation in the corneal epithelium and may cause clouding of the cornea. [3]
054.42 Dendritic keratitis; 054.43 Herpes simplex disciform keratitis; 054.44 Herpes simplex iridocyclitis; 054.49 Herpes simplex with other ophthalmic complications; 054.5 Herpetic septicemia; 054.6 Herpetic whitlow; 054.7 Herpes simplex with other specified complications 054.71 Visceral herpes simplex; 054.72 Herpes simplex meningitis; 054.73 ...
Herpes simplex viruses can affect areas of skin exposed to contact with an infected person. An example of this is herpetic whitlow , which is a herpes infection on the fingers; it was commonly found on dental surgeon 's hands before the routine use of gloves when treating patients.
Oral and/or genital herpes, herpetic gingivostomatitis, pharyngitis, eczema herpeticum, herpetic whitlow, herpes simplex keratitis, erythema multiforme, encephalitis, as well as other herpes simplex infections: Neuron (sensory ganglia) Close contact (oral or sexually transmitted infection) HHV-2: Herpes simplex virus-2 (HSV-2) α: Mucoepithelial
Corneal ulcer, also called keratitis, is an inflammatory or, more seriously, infective condition of the cornea involving disruption of its epithelial layer with involvement of the corneal stroma. [ 1 ] [ 2 ] [ 3 ] It is a common condition in humans particularly in the tropics and in farming. [ 4 ]
Keratoconjunctivitis is frequently caused by viral infections in and around the eyes. A particularly common cause of this is the herpes simplex virus.In some people, the infection may become chronic and keratoconjunctivitis may present during flare-ups of variable frequency.
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