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1,3-Dibromobenzene has been used as a starting material in the synthesis of antiviral Lufotrelvir, in human clinical trials for the treatment of COVID-19. [3] The first step is formylation of 1,3-dibromobenzene to 2,6-dibromobenzaldehyde, by lithiation with lithium diisopropylamide in THF , followed by quenching with dimethylformamide .
1,2-Dibromobenzene: 1,3-Dibromobenzene [1] 1,4-Dibromobenzene [2] [3] [4] Structure Molecular formula: C 6 H 4 Br 2: Molar mass: 235.906 g/mol Appearance colorless liquid colorless liquid white solid CAS number [583-53-9] [108-36-1] [106-37-6] Properties Density and phase: 1.9940 g/ml, liquid 1.9523 g/ml, liquid 1.84 g/ml, solid Solubility in ...
Nitrobenzenes are a group of nitro compounds consisting of one or more nitro groups as substituents on a benzene core. They have the formula C 6 H 6–n (NO 2) n, where n = 1–6 is the number of nitro groups.
Bromine is more electronegative than carbon (2.9 vs 2.5). Consequently, the carbon in a carbon–bromine bond is electrophilic, i.e. alkyl bromides are alkylating agents. [2] Carbon–halogen bond strengths, or bond dissociation energies are of 115, 83.7, 72.1, and 57.6 kcal/mol for bonded to fluorine, chlorine, bromine, or iodine, respectively ...
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If the benzene ring contains other substituents, it belongs in Category:Nitrobenzene derivatives Wikimedia Commons has media related to Nitrobenzenes . The main article for this category is Nitrobenzenes .
The most widely used synthetic route to DBA utilizes electrophilic borylation chemistry as the key transformation, [6] [7] which dates to 1969 from Seibert et al. [8] and 1998 from Eisch et al. [9] Starting with the commercially available chemical 1,2-dibromobenzene, lithium-halogen exchange [10] followed by silylation yields 1,2-bis(trimethylsilyl) benzene as the intermediate.
2,6-Dibromophenol, 1,3-Dibromo-2-hydroxybenzene 3,4-Dibromophenol, 1,2-Dibromo-4-hydroxybenzene 3,5-Dibromophenol, 1,3-Dibromo-5-hydroxybenzene Structural formula: CAS Number: 57383-80-9: 615-58-7: 28165-52-8: 608-33-3: 615-56-5: 626-41-5 PubChem: CID 34264 from PubChem: CID 12005 from PubChem: CID 34177 from PubChem: CID 11847 from PubChem ...
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