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The prognosis of schizophrenia is varied at the individual level. In general it has great human and economics costs. [ 1 ] It results in a decreased life expectancy of 12–15 years primarily due to its association with obesity , little exercise, and smoking , while an increased rate of suicide plays a lesser role. [ 1 ]
Paraphrenia is often associated with a physical change in the brain, such as a tumor, stroke, ventricular enlargement, or neurodegenerative process. [4] Research that reviewed the relationship between organic brain lesions and the development of delusions suggested that "brain lesions which lead to subcortical dysfunction could produce delusions when elaborated by an intact cortex".
Schizophrenia is a mental disorder characterized by significant alterations in perception, thoughts, mood, and behavior. [34] Symptoms are described in terms of positive, negative, and cognitive symptoms. [3] [35] The positive symptoms of schizophrenia are the same for any psychosis and are sometimes referred to as psychotic symptoms. These may ...
The symptoms of dissociative intoxication are also considered to mirror the symptoms of schizophrenia, including negative symptoms. [99] NMDA receptor antagonism, in addition to producing symptoms reminiscent of psychosis, mimics the neurophysiological aspects, such as reduction in the amplitude of P50, P300, and MMN evoked potentials. [100]
Symptoms of schizophrenia simplex include an absence of will, impoverished thinking and flattening of affect. There is a gradual deterioration of functioning with increased amotivation and reduced socialization. [6] [7] It is considered to be rarely diagnosed and is a schizophrenia without psychotic symptoms. [8]
Other psychiatric disorders must then be ruled out. In delusional disorder, mood symptoms tend to be brief or absent, and unlike schizophrenia, delusions are non-bizarre and hallucinations are minimal or absent. [8] Interviews are important tools to obtain information about the patient's life situation and history to help make a diagnosis.
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