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Methanesulfonic acid (MsOH, MSA) or methanesulphonic acid (in British English) is an organosulfuric, colorless liquid with the molecular formula CH 3 SO 3 H and structure H 3 C−S(=O) 2 −OH. It is the simplest of the alkylsulfonic acids ( R−S(=O) 2 −OH ).
General structure of a sulfonic acid with the functional group indicated in blue. In organic chemistry, sulfonic acid (or sulphonic acid) refers to a member of the class of organosulfur compounds with the general formula R−S(=O) 2 −OH, where R is an organic alkyl or aryl group and the S(=O) 2 (OH) group a sulfonyl hydroxide. [1]
Methanesulfonyl chloride is mainly used to give methanesulfonates by its reaction with alcohols in the presence of a non-nucleophilic base. [8] In contrast to the formation of toluenesulfonates from alcohols and p-toluenesulfonyl chloride in the presence of pyridine, the formation of methanesulfonates is believed to proceed via a mechanism wherein methanesulfonyl chloride first undergoes an ...
Methanesulfonic anhydride (Ms 2 O) is the acid anhydride of methanesulfonic acid. Like methanesulfonyl chloride (MsCl), it may be used to generate mesylates (methanesulfonyl esters). Preparation & purification
This reaction entails an acid-catalyzed Electrophilic aromatic substitution amidoalkylation, utilizing an N-hydroxymethylamide or N-hydroxymethylimide, which are also known as the Tscherniak-Einhorn reagents. The reaction is catalyzed by potent acids such as 85-100% sulfuric acid, p-toluenesulfonic acid, methanesulfonic acid, or trifluoroacetic ...
1 Chemical reactions with DNA. 2 See also. 3 References. Toggle the table of contents. Methyl methanesulfonate. ... Methanesulfonic acid methyl ester Methyl mesylate MMS.
Eaton's reagent [1] (10 wt% phosphorus pentoxide solution in methanesulfonic acid) is used as an alternative to polyphosphoric acid in chemical synthesis to promote acylation reactions. References [ edit ]
In organosulfur chemistry, a mesylate is any salt or ester of methanesulfonic acid (CH 3 SO 3 H). In salts, the mesylate is present as the CH 3 SO − 3 anion . When modifying the international nonproprietary name of a pharmaceutical substance containing the group or anion, the spelling used is sometimes mesilate (as in imatinib mesilate , the ...