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When switching antidepressants, your healthcare provider may recommend switching directly, cross-tapering or tapering down your dosage before you start using your new medication.
Other antidepressants include monoamine oxidase inhibitors , serotonin-norepinephrine reuptake inhibitors (SNRIs), atypical antidepressants and tricyclic antidepressants . Lots of acronyms, we know.
There is support for the effectiveness of switching people to a different SSRI; 50% of people that were non-responsive after taking one SSRI were responsive after taking a second type. Switching people with treatment-resistant depression to a different class of antidepressants may also be effective.
The authors attributed the relationship between severity and efficacy to a reduction of the placebo effect in severely depressed patients, rather than an increase in the effect of the medication. [11] Some researchers have questioned the statistical basis of this study suggesting that it underestimates the effect size of antidepressants. [12] [13]
This is a complete list of clinically approved prescription antidepressants throughout the world, as well as clinically approved prescription drugs used to augment antidepressants or mood stabilizers, by pharmacological and/or structural classification. Chemical/generic names are listed first, with brand names in parentheses.
The reality is, there’s no one-size-fits-all treatment. There are multiple types of antidepressants, and each person responds to them differently. How long a person takes an antidepressant varies.
[97] [90] [214] [84] [85] Differences in effectiveness between different antidepressants are small and not clinically meaningful. [215] [214] The small advantage of antidepressants over placebo is often statistically significant and is the basis for their regulatory approval, but is sufficiently modest that its clinical significance is doubtful.
Use of antidepressants during pregnancy may result in fetus abnormalities affecting functional development of the brain and behavior. [89] Studies have shown correlations between pregnant women treated with SNRIs and risk of hypertensive disorders, [90] preeclampsia, [91] miscarriage, [92] seizures in children, [93] and many other adverse affects.
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