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Drug tolerance or drug insensitivity is a pharmacological concept describing subjects' reduced reaction to a drug following its repeated use. Increasing its dosage may re-amplify the drug's effects; however, this may accelerate tolerance, further reducing the drug's effects.
An issue with this theory is that most addictive drugs cause an individual to build up a tolerance and the effects of the drug will decrease as an individual's tolerance increases. This requires individuals to use a higher dosage of the substance which in many causes can cause adverse side effects. [34] Dopamine is correlated with increased ...
Tolerability, however, is often relative to the severity of the medical condition a drug is designed to treat. [1] For instance, cancer patients may tolerate significant pain or discomfort during a chemotherapeutic study with the hope of prolonging survival or finding a cure, whereas patients experiencing a benign condition, such as a headache ...
An addictive personality refers to a hypothesized set of personality traits that make an individual predisposed to developing addictions.This hypothesis states that there may be common personality traits observable in people suffering from addiction; however, the lack of a universally agreed upon definition has marked the research surrounding addictive personality.
Drug intolerance or drug sensitivity refers to an inability to tolerate the adverse effects of a medication, generally at therapeutic or subtherapeutic doses. Conversely, a patient is said to be "tolerating" a drug when they can tolerate its adverse effects.
Substance dependence, also known as drug dependence, is a biopsychological situation whereby an individual's functionality is dependent on the necessitated re-consumption of a psychoactive substance because of an adaptive state that has developed within the individual from psychoactive substance consumption that results in the experience of withdrawal and that necessitates the re-consumption ...
The last image we have of Patrick Cagey is of his first moments as a free man. He has just walked out of a 30-day drug treatment center in Georgetown, Kentucky, dressed in gym clothes and carrying a Nike duffel bag. The moment reminds his father of Patrick’s graduation from college, and he takes a picture of his son with his cell phone.
Siegel suggested that compensatory CRs allow the organism to maintain a normal physiological state despite the administration of a drug and that they help to explain tolerance to drugs. The conditioned compensatory response may take place only in the case of subconscious learning, as the effects of conscious expectancies may tend to be in the ...