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Species of origin is designated with a three-letter prefix, e.g., hsa-miR-124 is a human (Homo sapiens) miRNA and oar-miR-124 is a sheep (Ovis aries) miRNA. Other common prefixes include "v" for viral (miRNA encoded by a viral genome) and "d" for Drosophila miRNA (a fruit fly commonly studied in genetic research).
A database of inverse miRNA target predictions, based on the RepTar algorithm that is independent of evolutionary conservation considerations and is not limited to seed pairing sites. database: website [17] RNA22: The first link (predictions) provides RNA22 predictions for all protein coding transcripts in human, mouse, roundworm, and fruit fly.
let-7 was later identified in humans as the first human miRNA , and is highly conserved across many species. [3] [4] Dysregulation of let-7 contributes to cancer development in humans by preventing differentiation of cells, leaving them stuck in a stem-cell like state. [1] let-7 is therefore classified as a tumor suppressor.
miRNA: Gene regulation: Most eukaryotes [14] Piwi-interacting RNA: piRNA: Transposon defense, maybe other functions: Most animals [15] [16] Small interfering RNA: siRNA: Gene regulation: Most eukaryotes [17] Short hairpin RNA: shRNA: Gene regulation: Most eukaryotes [18] Trans-acting siRNA: tasiRNA: Gene regulation: Land plants [19] Repeat ...
Drosha is a Class 2 ribonuclease III enzyme [5] that in humans is encoded by the DROSHA (formerly RNASEN) gene. [6] [7] [8] It is the primary nuclease that executes the initiation step of miRNA processing in the nucleus.
In humans, miR-125 family is composed of three homologs: hsa-miR-125a, hsa-miR-125b-1 and hsa-miR-125b-2. [7] MiR-125a has been found to be located on chromosome 19 , while paralogs of miR-125b are transcribed from two loci on chromosome 11 and chromosome 21 .
Hubstenberger et al. used fluorescence-activated particle sorting (a method based on the ideas of fluorescence-activated cell sorting) to purify processing bodies from human epithelial cells. From these purified processing bodies they were able to use mass spectrometry and RNA sequencing to determine which proteins and RNAs are found in ...
n/a Ensembl ENSG00000207703 n/a UniProt n a n/a RefSeq (mRNA) n/a n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 15: 88.61 – 88.61 Mb n/a PubMed search n/a Wikidata View/Edit Human MicroRNA 7-2 is a non-protein-coding gene product that in humans is encoded by the MIR7-2 gene. Function microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional ...