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Species of origin is designated with a three-letter prefix, e.g., hsa-miR-124 is a human (Homo sapiens) miRNA and oar-miR-124 is a sheep (Ovis aries) miRNA. Other common prefixes include "v" for viral (miRNA encoded by a viral genome) and "d" for Drosophila miRNA (a fruit fly commonly studied in genetic research).
miRNA: Gene regulation: Most eukaryotes [14] Piwi-interacting RNA: piRNA: Transposon defense, maybe other functions: Most animals [15] [16] Small interfering RNA: siRNA: Gene regulation: Most eukaryotes [17] Short hairpin RNA: shRNA: Gene regulation: Most eukaryotes [18] Trans-acting siRNA: tasiRNA: Gene regulation: Land plants [19] Repeat ...
let-7 was later identified in humans as the first human miRNA , and is highly conserved across many species. [3] [4] Dysregulation of let-7 contributes to cancer development in humans by preventing differentiation of cells, leaving them stuck in a stem-cell like state. [1] let-7 is therefore classified as a tumor suppressor.
The presence of miR-10 has been detected in a diverse range of bilaterian animals. It is one of the most widely distributed microRNAs in animals, it has been identified in numerous species including human, dog, cat, horse, cow, guinea pig, mouse, rat, common marmoset (Callithrix jacchus), common chimpanzee (Pan troglodytes), rhesus monkey (Macaca mulatta), Sumatran orangutan (Pongo abelii ...
•List of human protein-coding genes page 4 covers genes SLC17A8–ZZZ3 NB: Each list page contains 5000 human protein-coding genes, sorted alphanumerically by the HGNC-approved gene symbol. Follow the Python code link for information about updates to the list of genes on these pages.
A database of inverse miRNA target predictions, based on the RepTar algorithm that is independent of evolutionary conservation considerations and is not limited to seed pairing sites. database: website [17] RNA22: The first link (predictions) provides RNA22 predictions for all protein coding transcripts in human, mouse, roundworm, and fruit fly.
p53-deficient human gastric cancer cells, restoration of functional miR-34 inhibits cell growth and induces chemosensitization and apoptosis, indicating that miR-34 may restore p53 function. Restoration of miR-34 inhibits tumorsphere formation and growth, which is reported to be correlated to the self-renewal of cancer stem cells.
miR-33 is a family of microRNA precursors, which are processed by the Dicer enzyme to give mature microRNAs. [1] miR-33 is found in several animal species, including humans.In some species there is a single member of this family which gives the mature product mir-33.