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Carl Ferdinand Cori, ForMemRS [1] (December 5, 1896 – October 20, 1984) was a Czech-American biochemist and pharmacologist. He, together with his wife Gerty Cori and Argentine physiologist Bernardo Houssay , received a Nobel Prize in 1947 for their discovery of how the glucose derivative glycogen (animal starch) is broken down and ...
Carl Cori and Gerty Cori jointly won the 1947 Nobel Prize in Physiology or Medicine, for their discovery of the course of the catalytic conversion of glycogen, of which the Cori cycle is a part. Muscular activity requires ATP, which is provided by the breakdown of glycogen in the skeletal muscles.
Gerty Cori with her husband and fellow-Nobelist, Carl Ferdinand Cori, in 1947. [1]Gerty Theresa Cori (née Radnitz; August 15, 1896 – October 26, 1957 [2]) was a Bohemian-Austrian and American biochemist who in 1947 was the third woman to win a Nobel Prize in science, and the first woman to be awarded the Nobel Prize in Physiology or Medicine, for her role in the "discovery of the course of ...
It is also known as Cori's disease in honor of the 1947 Nobel laureates Carl Cori and Gerty Cori. Other names include Forbes disease in honor of clinician Gilbert Burnett Forbes (1915–2003), an American physician who further described the features of the disorder, or limit dextrinosis , due to the limit dextrin-like structures in cytosol . [ 2 ]
It was isolated and its activity characterized in detail by Carl F. Cori, Gerhard Schmidt and Gerty T. Cori. [ 23 ] [ 24 ] Arda Green and Gerty Cori crystallized it for the first time in 1943 [ 25 ] and illustrated that glycogen phosphorylase existed in either the a or b forms depending on its phosphorylation state, as well as in the R or T ...
She went on to research diseases related to the storage of glycogen where these enzymes were absent. [13] [14] She applied some of Carl Cori's findings to medical cases, [15] and confirmed the second known case of fructose bisphosphatase deficiency, a rare metabolic disorder, in 1970.
Glycogenesis is the process of glycogen synthesis or the process of converting glucose into glycogen in which glucose molecules are added to chains of glycogen for storage. This process is activated during rest periods following the Cori cycle, in the liver, and also activated by insulin in response to high glucose levels. [1]
Carl Ferdinand Cori (1896–1984) Czechoslovakia United States "for their discovery of the course of the catalytic conversion of glycogen" [46] Gerty Theresa Cori, née Radnitz (1896–1957) Bernardo Alberto Houssay (1887–1971) Argentina "for his discovery of the part played by the hormone of the anterior pituitary lobe in the metabolism of ...