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Hepatotoxicity (from hepatic toxicity) implies chemical-driven liver damage. Drug-induced liver injury (DILI) is a cause of acute and chronic liver disease caused specifically by medications and the most common reason for a drug to be withdrawn from the market after approval.
A hepatotoxin (Gr., hepato = liver) is a toxic chemical substance that damages the liver.. It can be a side-effect, but hepatotoxins are also found naturally, such as microcystins and pyrrolizidine alkaloids, or in laboratory environments, such as carbon tetrachloride, or far more pervasively in the form of ethanol (drinking alcohol).
Plasma perhexiline concentrations as low as 0.6mg/L> are known to cause nausea and dizziness; however, perhexiline is also known to cause hepatotoxicity and peripheral neuropathy at plasma concentrations >0.6mg/L. [9] [10] The symptoms of peripheral neuropathy include weakness or sensory loss and pain in the arms, hand, legs, and feet.
Users of Alli and Xenical, beware -- the diet drugs may cause liver failure, according to the U.S. Food and Drug Administration. In a statement released on May 26, the government agency said ...
It can also cause liver damage. [5] [6] The drug is a synthetic androgen and anabolic steroid and hence is an agonist of the androgen receptor (AR), the biological target of androgens like testosterone and dihydrotestosterone (DHT). [5] [8] It has strong anabolic effects and weak androgenic effects. [5]
One of those was carfentanil, an altered version of fentanyl that is said to be 100 times more potent, the CDC warned in a Dec. 5 alert. ... "Even a small amount can be fatal, as it can cause ...
Drug-drug interactions can be of serious concern for patients who are undergoing multi-drug therapies. [5] Coadministration of chloroquine , an anti-malaria drug, and statins for treatment of cardiovascular diseases has been shown to cause inhibition of organic anion-transporting polypeptides (OATPs) and lead to systemic statin exposure.
Related: One Common Habit That Could Be Damaging Your Liver. ... (Epigallocatechin-3-gallate, one of the catechins in green tea) were more likely to cause hepatotoxicity," Dr. Kim notes. "For ...