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The effect was first discovered accidentally in 1989, when a test of drug interactions with alcohol used grapefruit juice to hide the taste of the ethanol. [9] [10] A 2005 medical review advised patients to avoid all citrus juices until further research clarifies the risks. [11]
In addition, grapefruit can have the opposite effect on certain antihistamines, such as Allegra. These allergy medicines are absorbed into our body's cells through proteins known as transporters.
Grapefruit and grapefruit juice have been found to interact with numerous drugs, in many cases resulting in adverse effects. [4] This happens in two ways: one is that grapefruit can block an enzyme which metabolizes medication, [5] and if the drug is not metabolized, then the level of the drug in the blood can become too high, leading to an adverse effect. [5]
Amlodipine, sold under the brand name Norvasc among others, is a calcium channel blocker medication used to treat high blood pressure, coronary artery disease (CAD) [10] and variant angina (also called Prinzmetal angina or coronary artery vasospasm, among other names). [11]
A single glass of grapefruit juice can interfere with your body's ability to break down a medication. Here's how to protect your health.
Grapefruit decreased drug metabolism in humans, which likely represented the first clinical example of a food producing such an effect. Clinically, the concern is that a single judicious amount of grapefruit ingested even many hours beforehand would noticeably boost oral drug bioavailability and cause overdose toxicity.
Grapefruit has been known to cause similar effects when taken with some antihypertensives, as well as other PDE5 inhibitors like sildenafil (generic Viagra) and vardenafil.
A single glass of grapefruit juice can interfere with your body's ability to break down a medication. Here's how to protect your health. Grapefruit can interfere with certain medications