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The inflammation also causes further damage. The bones of the joint may also develop osteoarthritis, visible on a radiograph as small outcrops of bone, which further degrade the joint. [3] Osteoarthritis is a degenerative disease marked by the breakdown of cartilage between joints resulting in painful bone-to-bone contact. [4]
Osteoarthritis commonly affects the hands, feet, spine, and the large weight-bearing joints, such as the hips and knees, although in theory, any joint in the body can be affected. As osteoarthritis progresses, movement patterns (such as gait), are typically affected. [1] Osteoarthritis is the most common cause of a joint effusion of the knee. [15]
The Veterinary Journal is a monthly peer-reviewed scientific journal covering veterinary science and related topics. The journal was established in 1875 as The Veterinary Journal and Annals of Comparative Pathology and renamed The Veterinary Journal in 1900, then renamed British Veterinary Journal in 1949 before finally obtaining its current title in 1997.
Osteoarthritis and Cartilage is monthly peer-reviewed medical journal covering research in orthopedics and rheumatology. It is an official journal of the Osteoarthritis Research Society International , published on their behalf by Elsevier .
Osteoarthritis typically affects the weight-bearing joints, such as the back, knee and hip. Unlike rheumatoid arthritis, osteoarthritis is most commonly a disease of the elderly. The strongest predictor of osteoarthritis is increased age, likely due to the declining ability of chondrocytes to maintain the structural integrity of cartilage. [ 69 ]
In Practice is a publication published in conjunction with The Veterinary Record and provides continuing educational material for veterinary practitioners. It focuses on the topics of clinical and practice management. Reviews cover all species, but principally farm and companion animals, providing a regular update on clinical developments.
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Deracoxib is a coxib class nonsteroidal anti-inflammatory drug (NSAID). [3] Like other NSAIDs, its effects are caused by inhibition of cyclooxygenase (COX) enzymes. [7] At the doses used to treat dogs, deracoxib causes greater inhibition of COX-2 than of COX-1, [3] but at doses twice those recommended for use in dogs, deracoxib significantly inhibits COX-1 as well.