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The authors indicate that the serum based 14-3-3η marker is additive to the armamentarium of existing tools available to clinicians, and that there is adequate clinical evidence to support its clinical benefits in the management of patients diagnosed with rheumatoid arthritis (RA). [10] 14-3-3 proteins bind to and sequester the transcriptional ...
Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. [1] It typically results in warm, swollen, and painful joints. [1] Pain and stiffness often worsen following rest. [1] Most commonly, the wrist and hands are involved, with the same joints typically involved on both sides of the body. [1]
DRB1*01:01 is associated with rheumatoid arthritis, [13] in anti-Jk(a) mediated hemolytic transfusion reactions, [14] foliaceous pemphigus, [15] HTLV-1-associated myelopathy/tropical spastic paraparesis, and [16] lichen planus. [17] In lyme disease arthritis, *01:01 appears to play a role in presentation of triggering microbial antigens. [18]
HLA class II histocompatibility antigen, DRB1 beta chain is a protein that in humans is encoded by the HLA-DRB1 gene. [5] DRB1 encodes the most prevalent beta subunit of HLA-DR.
As of 2020, about 17.6 million people globally were living with rheumatoid arthritis, an autoimmune disease causing painful inflammation and swelling in joints. Scientists are still not sure as to ...
Despite the excellent performance of these immunoassays, for example CCP-assays, they only provide a sensitivity comparable with that of rheumatoid factor (RF). Moreover, analysis of the correlation of anti-CCP antibody titre with RA disease activity yielded conflicting results. [13] [14] However, novel test systems utilizing ACPA have been ...
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