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Postural orthostatic tachycardia syndrome (POTS) is a condition characterized by an abnormally large increase in heart rate upon sitting up or standing. [1] POTS is a disorder of the autonomic nervous system that can lead to a variety of symptoms, [10] including lightheadedness, brain fog, blurred vision, weakness, fatigue, headaches, heart palpitations, exercise intolerance, nausea ...
This would seem to support case studies reporting acrocyanosis as an unusual side effect for pediatric patients taking tricyclic antidepressants, as these medications can inhibit the reuptake of serotonin and thus increase their blood concentrations. [9] Acrocyanosis has been reported in association with many other medications and substances. [1]
POTS patients manage their symptoms with medication, diet, and preventative behaviors. Drugs such as midodrine, fludrocortisone, droxidopa, and pyridostigmine are sometimes prescribed to help stabilize blood pressure. Patients can work with their diet to ensure they are getting the crucial amount of fluid intake and increasing their intake of salt.
The main treatment for acral erythema is discontinuation of the offending drug, and symptomatic treatment to provide analgesia, lessen edema, and prevent superinfection. However, the treatment for the underlying cancer of the patient must not be neglected. Often, the discontinued drug can be substituted with another cancer drug or cancer treatment.
A skin biopsy for the measurement of epidermal nerve fiber density is an increasingly common technique for the diagnosis of small fiber peripheral neuropathy. [13] Physicians can biopsy the skin with a 3-mm circular punch tool and immediately fix the specimen in 2% paraformaldehyde lysine-periodate or Zamboni's fixative. [ 20 ]
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A man exhibiting the asymmetric symptoms of Harlequin syndrome. One half of the forehead is more red than the other. Harlequin syndrome , also known as " harlequin sign ", is a condition characterized by asymmetric sweating and flushing on the upper thoracic region of the chest, neck and face.
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