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  2. Melatonin as a medication and supplement - Wikipedia

    en.wikipedia.org/wiki/Melatonin_as_a_medication...

    The bioavailability of melatonin is between 2.5 and 50%. [6] [7] Melatonin is rapidly absorbed and distributed, reaching peak plasma concentrations after 60 minutes of administration, and is then eliminated. [6] Usual doses of exogenous melatonin of 1 to 12 mg produce melatonin concentrations 10 to 100 times higher than endogenous peak levels. [7]

  3. You’re probably taking too much melatonin—and using ... - AOL

    www.aol.com/finance/probably-taking-too-much...

    Nearly 30% of Americans say insomnia has a negative impact on their daily lives. It’s no wonder then that a growing number of people are reaching for melatonin supplements to help solve their ...

  4. Taking melatonin for sleep? What to know about potential ...

    www.aol.com/news/taking-melatonin-sleep-know...

    Melatonin supplements for sleep come with side effects and their use may raise safety concerns, experts say. There's little evidence they help with insomnia.

  5. How to Know If 6 Hours of Sleep Is Enough - AOL

    www.aol.com/know-6-hours-sleep-enough-235900599.html

    Dr. Polos also recommends avoiding watching TV or using your computer or phone at least 30 minutes before bed, as this can inhibit melatonin release and delay sleep onset.

  6. Melatonin - Wikipedia

    en.wikipedia.org/wiki/Melatonin

    Melatonin, an indoleamine, is a natural compound produced by various organisms, including bacteria and eukaryotes. [1] Its discovery in 1958 by Aaron B. Lerner and colleagues stemmed from the isolation of a substance from the pineal gland of cows that could induce skin lightening in common frogs.

  7. Delayed sleep phase disorder - Wikipedia

    en.wikipedia.org/wiki/Delayed_sleep_phase_disorder

    Side effects of melatonin may include sleep disturbance, nightmares, daytime sleepiness, and depression, though the current tendency to use lower doses has decreased such complaints. Large doses of melatonin can even be counterproductive: Lewy et al. [ 48 ] provide support to "the idea that too much melatonin may spill over onto the wrong zone ...

  8. Be cautious when using melatonin as a sleep aid - AOL

    www.aol.com/news/cautious-using-melatonin-sleep...

    Because the FDA doesn’t regulate dietary supplements like melatonin as strictly as prescription and over-the-counter drugs, buyers need to beware. Be cautious when using melatonin as a sleep aid ...

  9. Somnifacient - Wikipedia

    en.wikipedia.org/wiki/Somnifacient

    Melatonin is an endogenous hormone synthesized in the pineal gland in the brain involved in promoting sleep. [30] It activates both melatonin receptors MT1 and MT2 to produce beneficial effects on sleep, therefore being used exogenously for mild insomnia. [31]

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