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2. Melatonin as a medication and supplement - Wikipedia

   en.wikipedia.org/wiki/Melatonin_as_a_medication...

   The bioavailability of melatonin is between 2.5 and 50%. [6] [7] Melatonin is rapidly absorbed and distributed, reaching peak plasma concentrations after 60 minutes of administration, and is then eliminated. [6] Usual doses of exogenous melatonin of 1 to 12 mg produce melatonin concentrations 10 to 100 times higher than endogenous peak levels. [7]

3. 6-Hydroxymelatonin - Wikipedia

   en.wikipedia.org/wiki/6-Hydroxymelatonin

   6-Hydroxymelatonin (6-OHM) is a naturally occurring, endogenous, major active metabolite of melatonin. [ 1 ] 6-Hydroxymelatonin is produced as a result of the enzymatic conversion of melatonin through hydroxylation . [ 2 ]

4. The 6 best melatonin supplements - AOL

   www.aol.com/6-best-melatonin-supplements...

   Not only do the best melatonin supplements contain an appropriate dose of 1 to 5 milligrams, but they also come in a variety of forms — from capsules to lotions and even sprays — so you can ...

5. Sleep deprivation - Wikipedia

   en.wikipedia.org/wiki/Sleep_deprivation

   Sleep hygiene therapy is not helpful, however, when used as a monotherapy without the pairing of stimulus control therapy and sleep restriction therapy. [ 185 ] [ 173 ] Light stimulation affects the supraoptic nucleus of the hypothalamus, controlling circadian rhythm and inhibiting the secretion of melatonin from the pineal gland.

6. Insomnia - Wikipedia

   en.wikipedia.org/wiki/Insomnia

   Usage of melatonin as a treatment for insomnia in adults has increased from 0.4% between 1999 and 2000 to nearly 2.1% between 2017 and 2018. [164] While the use of melatonin in the short-term has been proven to be generally safe and it is shown to not be a dependent medication, side effects can still occur. [165]

7. Advanced sleep phase disorder - Wikipedia

   en.wikipedia.org/wiki/Advanced_sleep_phase_disorder

   Advanced Sleep Phase Disorder (ASPD), also known as the advanced sleep-phase type (ASPT) of circadian rhythm sleep disorder, is a condition that is characterized by a recurrent pattern of early evening (e.g. 7-9 PM) sleepiness and very early morning awakening (e.g. 2-4 AM).