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  2. Biochemistry of Alzheimer's disease - Wikipedia

    en.wikipedia.org/wiki/Biochemistry_of_Alzheimer's...

    The biochemistry of Alzheimer's disease, the most common cause of dementia, is not yet very well understood. Alzheimer's disease (AD) has been identified as a proteopathy: a protein misfolding disease due to the accumulation of abnormally folded amyloid beta (Aβ) protein in the brain. [1]

  3. Amyloid-beta precursor protein - Wikipedia

    en.wikipedia.org/wiki/Amyloid-beta_precursor_protein

    Cleavage by gamma secretase within the membrane-spanning domain after beta-secretase cleavage generates the amyloid-beta fragment; gamma secretase is a large multi-subunit complex whose components have not yet been fully characterized, but include presenilin, whose gene has been identified as a major genetic risk factor for Alzheimer's.

  4. Amyloid beta - Wikipedia

    en.wikipedia.org/wiki/Amyloid_beta

    The normal function of Aβ is not yet known. [9] Though some animal studies have shown that the absence of Aβ does not lead to any obvious loss of physiological function, [10] [11] several potential activities have been discovered for Aβ, including activation of kinase enzymes, [12] [13] protection against oxidative stress, [14] [15] regulation of cholesterol transport, [16] [17] functioning ...

  5. New study challenges amyloid-beta theory on cause for ... - AOL

    www.aol.com/study-challenges-amyloid-beta-theory...

    A main theory behind the cause of Alzheimer’s disease is the build-up of the protein amyloid-beta in the brain. Researchers from the University of Cincinnati provide evidence suggesting it’s ...

  6. Presenilin - Wikipedia

    en.wikipedia.org/wiki/Presenilin

    In patients with Alzheimer's disease (autosomal dominant hereditary), mutations in the presenilin proteins (PSEN1; PSEN2) or the amyloid precursor protein (APP) can be found. The majority of these cases carry mutant presenilin genes. An important part of the disease process in Alzheimer's disease is the accumulation of Amyloid beta (Aβ

  7. Shifts in brain activity may signal Alzheimer's long before ...

    www.aol.com/shifts-brain-activity-may-signal...

    Subtle changes in brain activity in the presence of both amyloid-beta and tau proteins may point to Alzheimer's disease, long before symptoms appear, a new study indicates.

  8. Alzheimer’s could be diagnosed 10 years earlier after world’s ...

    www.aol.com/alzheimer-could-diagnosed-10-years...

    Alzheimer’s disease could be diagnosed up to a decade earlier after the world’s biggest study of proteins is completed.. The research, which will begin in the UK this month, will aim to ...

  9. Reelin - Wikipedia

    en.wikipedia.org/wiki/Reelin

    ApoE4 is the primary genetic risk factor for late-onset Alzheimer's disease. This strong genetic association has led to the proposal that ApoE receptors play a central role in the pathogenesis of Alzheimer's disease. [176] [177] According to one study, reelin expression and glycosylation patterns are altered in Alzheimer's disease.

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