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Paclitaxel, sold under the brand name Taxol among others, is a chemotherapy medication used to treat ovarian cancer, esophageal cancer, breast cancer, lung cancer, Kaposi's sarcoma, cervical cancer, and pancreatic cancer. [11] It is administered by intravenous injection. [11] There is also an albumin-bound formulation. [11]
Crystal structure of paclitaxel. Paclitaxel total synthesis in organic chemistry is a major ongoing research effort in the total synthesis of paclitaxel (Taxol). [ 1 ] This diterpenoid is an important drug in the treatment of cancer but, also expensive because the compound is harvested from a scarce resource, namely the Pacific yew ( Taxus ...
The Holton Taxol total synthesis, published by Robert A. Holton and his group at Florida State University in 1994, was the first total synthesis of Taxol (generic name: paclitaxel). [ 1 ] [ 2 ] The Holton Taxol total synthesis is a good example of a linear synthesis .
Chemical structure of paclitaxel, trade name Taxol®. Date: February 2007: Source: ... Description=Chemcal structure of paclitaxel, trade name Taxol®. ...
English: Structural diagram of Paclitaxel (Taxol). SVG format to supersede existing PNG image. Created by R. Terrett in ACDChemSketch 10.0. Stereochemistry obtained from FDA document 'ABRAXANE for Injectable Suspension (paclitaxel protein-bound particles for injectable suspension)(albumin-bound)' [1]
The structure of paclitaxel, a widely used mitotic inhibitor. A mitotic inhibitor, microtubule inhibitor, or tubulin inhibitor, is a drug that inhibits mitosis, or cell division, and is used in treating cancer, gout, and nail fungus. These drugs disrupt microtubules, which are structures that pull the chromosomes apart when a cell divides.
Nicolaou Taxol total synthesis overview from raw material perspective. The Nicolaou Taxol total synthesis, published by K. C. Nicolaou and his group in 1994 concerns the total synthesis of taxol. [1] Taxol is an important drug in the treatment of cancer but also expensive because the compound is harvested from a scarce resource, namely the ...
The bottom part of ring B was constructed by nucleophilic addition to the aldehyde of 2.1 (scheme 2) with dibenzyl acetal of 2-bromobenzaldehyde 2.2 as its aryllithium.This step is much in common with the B ring synthesis in the Nicolaou Taxol total synthesis except that the aldehyde group is located at ring A and not ring B.