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The drug does not cause an individual to become unconscious, merely to be sedated. [12] It is also useful for the treatment of prolonged (lasting over five minutes) seizures. [14] Midazolam can be given by mouth, intravenously, by injection into a muscle, by spraying into the nose, or through the cheek.
Midazolam – It is a fast-acting and the most lipophilic of all benzodiazepine and rapidly crosses the blood–brain barrier. It is a gamma-aminobutyric acid (GABA) agonist. [9] Usual doses for midazolam are 1 mg to 2 mg where the older people receive smaller doses and obese people receive higher doses.
Midazolam collects in the body's fatty tissues, so a possible complication includes prolonged sedation. As a result, the elderly, the obese, and those with kidney or liver disease are more vulnerable to prolonged sedation with midazolam. Respiratory depression is also associated with midazolam when given in high doses.
First-pass metabolism may occur in the liver (for propranolol, lidocaine, clomethiazole, and nitroglycerin) or in the gut (for benzylpenicillin and insulin). [4] The four primary systems that affect the first pass effect of a drug are the enzymes of the gastrointestinal lumen, [5] gastrointestinal wall enzymes, [6] [7] [8] bacterial enzymes [5] and hepatic enzymes.
As you age, your metabolism slows, which may play a role in how quickly semaglutide works in your body. It's very common for weight gain to start during perimenopause, a few years before menopause ...
The action of drugs on the human body (or any other organism's body) is called pharmacodynamics, and the body's response to drugs is called pharmacokinetics. The drugs that enter an individual tend to stimulate certain receptors, ion channels, act on enzymes or transport proteins. As a result, they cause the human body to react in a specific way.
A medical professional applies nose drops. Nasal administration, popularly known as snorting, is a route of administration in which drugs are insufflated through the nose.It can be a form of either topical administration or systemic administration, as the drugs thus locally delivered can go on to have either purely local or systemic effects.
One difference is that Cialis is active in the body for longer than other oral ED meds, meaning its side effects can last longer too. ... for shorter periods and may make this side effect subside ...