Search results
Results from the WOW.Com Content Network
Interkinetic nuclear migration is a feature of developing neuroepithelia and is characterized by the periodic movement of the cell’s nucleus with the progression of the cell cycle. Developing neuroepithelia are tissues composed of neural progenitor cells, each spanning the entire thickness of the epithelium from the ventricular surface to the ...
Axonal transport, also called axoplasmic transport or axoplasmic flow, is a cellular process responsible for movement of mitochondria, lipids, synaptic vesicles, proteins, and other organelles to and from a neuron's cell body, through the cytoplasm of its axon called the axoplasm. [1]
Drug delivery to the brain is the process of passing therapeutically active molecules across the blood–brain barrier into the brain.This is a complex process that must take into account the complex anatomy of the brain as well as the restrictions imposed by the special junctions of the blood–brain barrier.
Gap junctions are the main site of cell-cell signaling or communication that allow small molecules to diffuse between adjacent cells. In vertebrates, gap junctions are composed of transmembrane proteins called connexins. They form hexagonal pores or channels through which ions, sugars, and other small molecules can pass.
At a chemical synapse, one neuron releases neurotransmitter molecules into a small space (the synaptic cleft) that is adjacent to another neuron. The neurotransmitters are contained within small sacs called synaptic vesicles, and are released into the synaptic cleft by exocytosis.
In both images neurons are stained with a somatodendritic marker, microtubule associated protein (red). In the right image, synaptic vesicles are stained in green (yellow where the green and red overlap). Scale bar = 25 μm. [3] Synaptic vesicles are relatively simple because only a limited number of proteins fit into a sphere of 40 nm diameter.
Neurotransmitter transporters are a class of membrane transport proteins that span the cellular membranes of neurons. Their primary function is to carry neurotransmitters across these membranes and to direct their further transport to specific intracellular locations. There are more than twenty types of neurotransmitter transporters. [1]
These endocytosed molecules are sorted into early endosomes within the cell, which serves to further sort these substances to the correct final destination (in the same way the Golgi does in the secretory pathway). From here, the early endosome starts a cascade of transport where the cargo is eventually hydrolyzed inside the lysosome for ...