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  2. CD4 - Wikipedia

    en.wikipedia.org/wiki/CD4

    T-cells play a large part in autoinflammatory diseases. [25] When testing a drug's efficacy or studying diseases, it is helpful to quantify the amount of T-cells on fresh-frozen tissue with CD4+, CD8+, and CD3+ T-cell markers (which stain different markers on a T-cell – giving different results). [26]

  3. T helper cell - Wikipedia

    en.wikipedia.org/wiki/T_helper_cell

    This decline in killing of CD4 + T cells results in the virus being produced for a longer period (the infected CD4 + T cells are not killed as quickly), increasing the proliferation of the virus, and accelerating the development of the disease. Antibody class switching declines significantly once helper T cell function fails.

  4. T cell - Wikipedia

    en.wikipedia.org/wiki/T_cell

    Markers of T cell activation include CD69, CD71 and CD25 (also a marker for Treg cells), and HLA-DR (a marker of human T cell activation). CTLA-4 expression is also up-regulated on activated T cells, which in turn outcompetes CD28 for binding to the B7 proteins. This is a checkpoint mechanism to prevent over activation of the T cell.

  5. List of human clusters of differentiation - Wikipedia

    en.wikipedia.org/wiki/List_of_human_clusters_of...

    BTLA (B- and T-lymphocyte attenuator); expression induced during activation of T cells. Like PD1 and CTLA4, BTLA interacts with a B7 homolog, B7H4. However, unlike PD-1 (CD279) and CTLA-4 (CD152), BTLA displays T-Cell inhibition via interaction with tumor necrosis family receptors (TNF-R), not just the B7 family of cell surface receptors.

  6. IL2RA - Wikipedia

    en.wikipedia.org/wiki/IL2RA

    [19] [20] High expression of CD25 is also found on TCR activated conventional T cells (both CD8+ and CD4+ T lymphocytes), where it is considered to be a marker of T cell activation. [21] Additionally, expression of the IL-2 receptor alpha subunit can be found in non-lymphoid tissues such as lungs ( alveolar macrophages ), liver ( Kupffer cells ...

  7. Immunological synapse - Wikipedia

    en.wikipedia.org/wiki/Immunological_synapse

    The process of formation begins when the T-cell receptor binds to the peptide:MHC complex on the antigen-presenting cell and initiates signaling activation through formation of microclusters/lipid rafts. Specific signaling pathways lead to polarization of the T-cell by orienting its centrosome toward the site of the immunological synapse. The ...

  8. Signaling lymphocytic activation molecule - Wikipedia

    en.wikipedia.org/wiki/Signaling_lymphocytic...

    Signaling lymphocytic activation molecule (SLAM) is a family of genes. Homophilic binding between SLAMs is involved in cell-to-cell adhesion during antigen presentation. [1] [2] Signaling lymphocytic activation molecules are a CD2-related surface receptor expressed by activated phagocytes, T helper cells, and platelets. [3]

  9. Regulatory T cell - Wikipedia

    en.wikipedia.org/wiki/Regulatory_T_cell

    All T cells derive from progenitor cells in the bone marrow, which become committed to their lineage in the thymus.All T cells begin as CD4-CD8-TCR- cells at the DN (double-negative) stage, where an individual cell will rearrange its T cell receptor genes to form a unique, functional molecule, which they, in turn, test against cells in the thymic cortex for a minimal level of interaction with ...