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2. IGF-1 LR3 - Wikipedia

   en.wikipedia.org/wiki/IGF-1_LR3

   Long arginine 3-IGF-1, abbreviated as IGF-1 LR3 or LR3-IGF-1, is a synthetic protein and lengthened analogue of human insulin-like growth factor 1 (IGF-1). [1] [2] It differs from native IGF-1 in that it possesses an arginine instead of a glutamic acid at the third position in its amino acid sequence ("arginine 3"), and also has an additional 13 amino acids at its N-terminus (MFPAMPLLSLFVN ...

3. Insulin-like growth factor - Wikipedia

   en.wikipedia.org/wiki/Insulin-like_growth_factor

   The IGF "axis" is also commonly referred to as the Growth Hormone/IGF-1 Axis. Insulin-like growth factor 1 (commonly referred to as IGF-1 or at times using Roman numerals as IGF-I) is mainly secreted by the liver as a result of stimulation by growth hormone (GH). IGF-1 is important for both the regulation of normal physiology, as well as a ...

4. Insulin-like growth factor 1 - Wikipedia

   en.wikipedia.org/wiki/Insulin-like_growth_factor_1

   Production is stimulated by growth hormone (GH). Most of IGF-1 is bound to one of 6 binding proteins (IGF-BP). IGFBP-1 is regulated by insulin. IGF-1 is produced throughout life; the highest rates of IGF-1 production occur during the pubertal growth spurt. [12] The lowest levels occur in infancy and old age. [13] [14]

5. Insulin-like growth factor 1 receptor - Wikipedia

   en.wikipedia.org/wiki/Insulin-like_growth_factor...

   The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by a hormone called insulin-like growth factor 1 and by a related hormone called IGF-2. It belongs to the large class of tyrosine kinase receptors. This receptor mediates the effects of IGF-1 ...

6. Insulin-like growth factor-binding protein - Wikipedia

   en.wikipedia.org/wiki/Insulin-like_growth_factor...

   IGF-1 binds to IGFBP-3 in a 1:1 molar ratio. IGF-BP also binds to IGF-1 inside the liver, allowing growth hormone to continuously act upon the liver to produce more IGF-1. IGF binding proteins (IGFBPs) are proteins of 24 to 45 kDa. All six IGFBPs share 50% homology with each other and have binding affinities for IGF-I and IGF-II at the same ...

7. des (1-3)IGF-1 - Wikipedia

   en.wikipedia.org/wiki/Des(1-3)IGF-1

   As a result of this difference, it has considerably reduced binding to the insulin-like growth factor-binding proteins (IGFBPs) and enhanced potency (about 10-fold in vivo) relative to IGF-1. [1] [2] [3] [5] The amino acid sequence of des(1-3)IGF-1 is TLCGAELVDA LQFVCGDRGF YFNKPTGYGS SSRRAPQTGI VDECCFRSCD LRRLEMYCAP LKPAKSA. [5]