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Phenytoin elimination kinetics show mixed-order, non-linear elimination behaviour at therapeutic concentrations. Where phenytoin is at low concentration it is cleared by first order kinetics, and at high concentrations by zero order kinetics. A small increase in dose may lead to a large increase in drug concentration as elimination becomes ...
“Testosterone can increase sexual desire in all people, but just having a higher testosterone level in and of itself is not going to improve orgasms,” explains Johnson. “That said, for ...
Valproates can either decrease or increase the levels of ethosuximide; however, combinations of valproates and ethosuximide had a greater protective index than either drug alone. [14] It may elevate serum phenytoin levels.
Phenytoin, a CYP2C9 inducer, would increase its activity and the rate of warfarin breakdown, thereby reducing its efficacy. [25] Patients should avoid the co-administration of warfarin and phenytoin. In cases where both drugs must be used together, warfarin dosing may be titrated up to cope with the reduced efficacy. [26]
There may be an increase in the clearance and resultant decrease in the blood concentration of lamotrigine, phenytoin, and to a lesser extent carbamazepine, and possibly decreases the level of levetiracetam and the active oxcarbazepine metabolite, the monohydroxy derivative. [94]
Medications that may cause excessive hair growth include anabolic steroids, testosterone, cyclosporine (Sandimmune), minoxidil (Rogaine), danazol (Danocrine) and phenytoin (Dilantin®), per the ...
Healthy New Year’s resolutions have a way of, well, sort of fizzling for most of us. But you don’t have to make sweeping changes that—let’s face it—are nearly impossible to keep! There ...
Likewise, CYP2D6 inhibitors such as paroxetine or fluoxetine can reduce chlorpromazine clearance, increasing serum levels of chlorpromazine and potentially its adverse effects. [5] Chlorpromazine also reduces phenytoin levels and increases valproic acid levels. [5]