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At higher doses, niacin has been used to treat high cholesterol and triglyceride levels, since it can help lower LDL (“bad”) cholesterol and raise levels of HDL (“good”) cholesterol.
Laropiprant is a prostaglandin D2 binding drug shown to reduce niacin-induced vasodilation and flushing side effects. [47] [93] [94] A clinical trial showed no additional efficacy of Tredaptive in lowering cholesterol when used together with other statin drugs, but did show an increase in other side effects. [95]
Acipimox (trade name Olbetam in Europe) is a niacin derivative used as a lipid-lowering agent.It reduces triglyceride levels and increases HDL cholesterol. It may have less marked adverse effects than niacin, although it is unclear whether the recommended dose is as effective as standard doses of niacin.
Pharmacologic (1- to 3-gram/day) niacin doses increase HDL levels by 10–30%, [61] making it the most powerful agent to increase HDL-cholesterol. [ 62 ] [ 63 ] A randomized clinical trial demonstrated that treatment with niacin can significantly reduce atherosclerosis progression and cardiovascular events. [ 64 ]
For example, lowering your LDL cholesterol by 1 millimole per liter (mmol/L) can reduce your risk of major vascular events by about 20 percent — regardless of your initial LDL level.
Here’s everything you need to know about how to lower cholesterol and why this marker of cardiovascular health is so important.
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