Search results
Results from the WOW.Com Content Network
Deafness in animals can occur as either unilateral (one ear affected) or bilateral (both ears affected). This occurrence of either type of deafness seems to be relatively the same in both mixed-breed animals and pure-breed animals. [5] Research has found a significant association between deafness in dogs and the pigment genes piebald and merle ...
Furthermore, there are multiple genes responsible for blue eyes, and several of these genes are not linked to masking, white coats or deafness, such as the dominant blue eye (DBE) gene carried by Ojos Azules. Another example is a mutation in the TYR gene causing point coloration, a form of partial albinism seen in Siamese cats and related breeds.
Schematic structures of dysferlin, myoferlin, and otoferlin; three ferlin proteins that are associated with human diseases. Lack of functional dysferlin can cause a group of muscular dystrophies knows as dysferlinopathies. Myoferlin is highly expressed in several types of cancer, and mutations in otoferlin can cause deafness.
Mutations in the gene encoding otoferlin are a cause of a neurosensory nonsyndromic recessive deafness, DFNB9.The diagnosis is identified by molecular genetic testing.. In October 2023 two small clinical trials for a gene therapy restoring the defective Otoferlin via an adeno-associated virus (AAVs) have been announced.
In some breeds of cats congenital sensorineural deafness is very common, with most white cats (but not albinos) being affected, particularly if they also have blue eyes. [1] The gene responsible for this defect is the KIT gene, and the disease is studied in the hope that it may shed light on the causes of hereditary deafness in humans. [8]
Already, researchers are testing mircoRNA-based strategies in animals and early human studies to treat cancer and infectious diseases. “We know from genetic research that cells and tissues do ...
[3] [14] Additionally, hearing loss is not as common as in type 2. [3] Rarely, cleft lip has been reported in this form of Waardenburg syndrome. [15] Type 4 can also be caused by a mutation in SOX10 (the same gene as in type 2E), in which it is known as type 4C; hearing loss is very common and severe in this type. [16]
Get AOL Mail for FREE! Manage your email like never before with travel, photo & document views. Personalize your inbox with themes & tabs. You've Got Mail!