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Corticobasal degeneration (CBD) is a rare neurodegenerative disease involving the cerebral cortex and the basal ganglia. [1] CBD symptoms typically begin in people from 50 to 70 years of age, and typical survival before death is eight years.
Corticobasal syndrome (CBS) is a rare, progressive atypical Parkinsonism syndrome and is a tauopathy related to frontotemporal dementia. [ 1 ] [ 2 ] CBS is typically caused by the deposit of tau proteins forming in different areas of the brain.
The cause of the condition is uncertain, but involves the accumulation of tau protein within the brain. Medications such as levodopa and amantadine may be useful in some cases. [1] PSP affects about six people per 100,000. [1] The first symptoms typically occur at 60–70 years of age. Males are slightly more likely to be affected than females. [1]
Neurodegenerative conditions and Parkinson-plus syndromes that can cause parkinsonism include: [6] Corticobasal degeneration [6] Dementia with Lewy bodies [6] The relationship (if any) with essential tremor is not clear. [7] Frontotemporal dementia (Pick's disease) [8] Gerstmann–Sträussler–Scheinker syndrome [6] Huntington's disease [6]
Causes: Mutations in the MAPT gene. [1] Diagnostic method: Clinical criteria, molecular genetic analysis, and brain imaging. [2] Differential diagnosis: Pick's disease, sporadic progressive supranuclear palsy, corticobasal degeneration, Parkinson-plus syndromes, dementia with Lewy bodies, Parkinson's disease, and multiple system atrophy. [2 ...
Veronica Brown lived with chronic fatigue, depression, and anxiety for over 10 years before she learned they were early signs of Parkinson's disease. Here's how she found relief after diagnosis.
The symptoms of this dementia depend on where in the brain the strokes occurred and whether the blood vessels affected were large or small. [13] Repeated injury can cause progressive dementia over time, while a single injury located in an area critical for cognition such as the hippocampus, or thalamus, can lead to sudden cognitive decline. [69]
Today's NYT Connections puzzle for Friday, December 13, 2024The New York Times
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