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Donepezil is a centrally acting reversible acetylcholinesterase inhibitor and structurally unrelated to other anticholinesterase agents. [8] [5] Common side effects include nausea, trouble sleeping, aggression, diarrhea, feeling tired, and muscle cramps. [8] [11] Serious side effects may include abnormal heart rhythms, urinary incontinence, and ...
Memantine/donepezil, sold under the brand name Namzaric among others, is a fixed dose combination medication used for the treatment of dementia of the Alzheimer's type. [1] It contains memantine, as the hydrochloride, a NMDA receptor antagonist; and donepezil as the hydrochloride, an acetylcholinesterase inhibitor. [1] It is taken by mouth. [1]
As MCI may represent a prodromal state to clinical Alzheimer's dementia, treatments for Alzheimer's disease could potentially be useful. [26] Of these, rivastigmine failed to stop or slow progression to Alzheimer's disease or to improve cognitive function for individuals with mild cognitive impairment; [ 27 ] donepezil showed only minor, short ...
After adjusting for sociodemographic and lifestyle factors, family history of dementia, baseline cognitive function and medications that affect cognition, the researchers analyzed whether there ...
They are generally used to treat Alzheimer's disease and dementia. [6] If a benefit occurs, it is generally during the second or third month after starting. [6] It is difficult to determine which ChEI has greater efficacy, due to design flaws in head-to-head comparison studies. [11] Pyridostigmine is used in the treatment of myasthenia gravis. [12]
Dementia prevention is a critical area of research, as experts want to understand what people can do to decrease dementia risk. A recent study found that more than 5 years of taking medications ...
Not only that, they had a 52 percent lower risk of vascular dementia, and a 39 percent lower risk of Alzheimer’s dementia. People who took SGLT-2 inhibitors for longer periods of time seemed to ...
The clinical guidelines for medication management in people with dementia recommend trialing an AChE inhibitor for people with early- to mid-stage dementia. These guidelines, known as the Medication Appropriateness Tool for Comorbid Health conditions in Dementia (MATCH-D) , suggest that these medicines are at least considered.
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