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Postherpetic neuralgia is the most common long-term complication of herpes zoster, and occurs in approximately 20% of patients with shingles. [2] Risk factors for PHN include older age, severe prodrome or rash , severe acute zoster pain, ophthalmic involvement, immunosuppression , and chronic conditions such as diabetes mellitus and lupus . [ 1 ]
The short- and long-term pain caused by shingles outbreaks originates from inflammation of affected nerves due to the widespread growth of the virus in those areas. [47] As with chickenpox and other forms of alpha-herpesvirus infection, direct contact with an active rash can spread the virus to a person who lacks immunity to it.
These anti-viral medications work best when taken at the first sign of outbreak, and can help prevent any long-term side effects of the virus, like long-term nerve pain, known as postherpetic ...
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This nerve pain may not respond well to standard pain treatments including NSAIDS and opioids. Medication specifically for nerve pain such as tricyclic antidepressants and gabapentin have been shown to be effective for the neuropathic pain and post-herpetic neuralgia common with RHS. [2]
Shingles, also called zoster or herpes zoster, is a viral infection that affects the nerves.
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