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A cancer syndrome or family cancer syndrome is a genetic disorder in which inherited genetic mutations in one or more genes predisposes the affected individuals to the development of cancers and may also cause the early onset of these cancers. Although cancer syndromes exhibit an increased risk of cancer, the risk varies.
The central role of DNA damage and epigenetic defects in DNA repair genes in carcinogenesis. DNA damage is considered to be the primary cause of cancer. [17] More than 60,000 new naturally-occurring instances of DNA damage arise, on average, per human cell, per day, due to endogenous cellular processes (see article DNA damage (naturally occurring)).
Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body. [2] [7] These contrast with benign tumors, which do not spread. [7] Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements. [1]
Clonal expansion is the signature of natural selection in cancer. Cancer therapies act as a form of artificial selection, killing sensitive cancer cells, but leaving behind resistant cells. Often the tumor will regrow from those resistant cells, the patient will relapse, and the therapy that had been previously used will no longer kill the ...
Although a DNA repair deficiency can predispose a cell lineage to develop cancer, increased (rather than decreased) expression of a repair capability may also emerge in the progression of cancer cell lineages, and this capability may be clinically important as reviewed by Lingg et al. [9] For instance, the DNA repair gene DMC1 encodes a protein ...
Aside from cancer linked to chronic smoking, there was no significant history of breast cancer in my family. Meanwhile, the nutrition company I had co-founded, Yumi, had already thrown me down the ...
They can cause cancer by turning the receptor permanently on (constitutively), even without signals from outside the cell. Ras is a small GTPase that hydrolyses GTP into GDP and phosphate. Ras is activated by growth factor signaling (i.e., EGF, TGFbeta) and acting as a binary switch (on/off) in growth signaling pathways.
Wilson left her followers with a vague update, informing her audience that the couple was pausing their journey while she took care of her father as his health continued to deteriorate (he had ...
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