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Cimetidine, sold under the brand name Tagamet among others, is a histamine H 2 receptor antagonist that inhibits stomach acid production. [ 1 ] [ 9 ] [ 10 ] It is mainly used in the treatment of heartburn and peptic ulcers .
They are mediators and have a variety of strong physiological effects, such as regulating the contraction and relaxation of smooth muscle tissue. [8] There are many prostaglandins with many effects. Prostaglandin E2 has effects including reducing gastric acid and increasing gastric mucus, which among other effects treat acid-related disorders. [9]
Cimetidine was the prototypical histamine H 2 receptor antagonist from which later drugs were developed. Cimetidine was the culmination of a project at Smith, Kline & French (SK&F; now GlaxoSmithKline) by James W. Black, C. Robin Ganellin, and others to develop a histamine receptor antagonist that would suppress stomach acid secretion.
Dr. Vincent M. Pedre III, MD, FMCP, says acid reflux, also known as gastroesophageal reflux disease (GERD), is a condition that affects up to 20 percent of the American population. Some sources ...
The proton pump is the terminal stage in gastric acid secretion, being directly responsible for secreting H + ions into the gastric lumen, making it an ideal target for inhibiting acid secretion. [ citation needed ] Because the H,K-ATPase is the final step of acid secretion, an inhibitor of this enzyme is more effective than receptor ...
Uncommon Ozempic Side Effects. Less-common side effects can include excess air or gas in your stomach, burping, heartburn, indigestion, fast heartbeat, low blood sugar, low energy and fatigue, or ...
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