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Phage therapy, viral phage therapy, or phagotherapy is the therapeutic use of bacteriophages for the treatment of pathogenic bacterial infections. [ 1 ] [ 2 ] [ 3 ] This therapeutic approach emerged at the beginning of the 20th century but was progressively replaced by the use of antibiotics in most parts of the world after the Second World War .
Phage therapy is a technique that was discovered before antibiotics, but fell to the wayside as antibiotics became predominate. It is now being considered as a potential solution to increasing antimicrobial resistance. Bacteriophages, viruses that only infect bacteria, can specifically target the bacteria of interest and inject their genome ...
Since bacteria become resistant against a single phage, d'Herelle suggested using "phage cocktails" containing different phage strains. Phage therapy soon became a boom, and a great hope in medicine. In 1924, 25 January, d'Hérelle received the honorary doctorate of the University of Leiden , [ 14 ] as well as the Leeuwenhoek medal , which is ...
Presently, phage therapy for humans is available only at the Phage Therapy Center in the Republic of Georgia and in Poland. [56] However, on January 2, 2007, the United States FDA gave Omnilytics approval to apply its E. coli O157:H7 killing phage in a mist, spray or wash on live animals that will be slaughtered for human consumption. [ 57 ]
The 'Nuts and Bolts' of Phage Therapy. a special issue of the journal, Current Pharmaceutical Biotechnology, consisting of six articles on phage therapy, plus an editorial. Carnazza, S., Guglielmino, S. eds. 2010. Phage Display As a Tool for Synthetic Biology. Nova Science Publishers, Hauppauge, New York. ISBN 978-1-60876-987-2, Google Books
Phage therapy has gained recent attention in the United States as an alternative to standard antibiotic therapy. [ 5 ] [ 6 ] [ 7 ] It has been in practice for just over 100 years in countries such as Russia and Georgia , but due to the recent clinical attention of antibiotic resistance , Western countries have slowly been integrating phage ...
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Transmission electron micrograph of multiple bacteriophages attached to a bacterial cell wall. A phageome is a community of bacteriophages and their metagenomes localized in a particular environment, similar to a microbiome. [1] [2] Phageome is a subcategory of virome, which is all of the viruses that are associated with a host or environment. [3]